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TST (gene)

From Wikipedia, the free encyclopedia
TST
Identifiers
AliasesTST, RDS, thiosulfate sulfurtransferase
External IDsOMIM: 180370; MGI: 98852; HomoloGene: 37759; GeneCards: TST; OMA:TST - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003312
NM_001270483

NM_009437

RefSeq (protein)

NP_001257412
NP_003303

NP_033463

Location (UCSC)Chr 22: 37.01 – 37.02 MbChr 15: 78.28 – 78.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thiosulfate sulfurtransferase is an enzyme that in humans is encoded by the TST gene.[5][6]

The product of this gene is a mitochondrial matrix enzyme that is encoded by the nucleus. It may play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes.

The gene product contains two highly conservative domains (rhodanese homology domains), suggesting these domains have a common evolutionary origin.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128311Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044986Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pallini R, Guazzi GC, Cannella C, Cacace MG (Dec 1991). "Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes". Biochem Biophys Res Commun. 180 (2): 887–93. doi:10.1016/S0006-291X(05)81148-9. PMID 1953758.
  6. ^ a b "Entrez Gene: TST thiosulfate sulfurtransferase (rhodanese)".

Further reading

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