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Hemoglobin subunit zeta

From Wikipedia, the free encyclopedia
HBZ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHBZ, HBZ-T1, HBZ1, hemoglobin subunit zeta, HBAZ
External IDsOMIM: 142310; MGI: 96019; HomoloGene: 110705; GeneCards: HBZ; OMA:HBZ - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005332

NM_010405

RefSeq (protein)

NP_005323

NP_034535

Location (UCSC)Chr 16: 0.14 – 0.15 MbChr 11: 32.23 – 32.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.[5][6]

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130656Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055609Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  6. ^ a b "Entrez Gene: HBZ hemoglobin, zeta".

Further reading

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