Pimagedin (aminogvanidin) je lek koji je istraživan za moguću primenu u tretmanu dijabetičke nefropatije.[5] Pimagedin je inhibitor diaminske oksidaze i sintaze azot oksida. On deluje tako što snižava nivoe krajnjih proizvoda glikacije putem interakcije sa 3-dezoksiglukozonom.

Pimagedin
Skeletal formula of a pimagedine minor tautomer
Skeletal formula of a pimagedine minor tautomer
Skeletal formula of a pimagedine minor tautomer with all explicit hydrogens added
Skeletal formula of a pimagedine minor tautomer with all explicit hydrogens added
Spacefill model of a pimagedine minor tautomer
IUPAC ime
Identifikacija
CAS registarski broj 79-17-4 DaY
PubChem[1][2] 2146
ChemSpider[3] 2061 DaY
UNII SCQ4EZQ113 DaY
ChEMBL[4] CHEMBL225304 DaY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula CH6N4
Molarna masa 74.09 g mol−1
log P −1,475
Srodna jedinjenja
Srodna jedinjenja

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Reference

uredi
  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. W Kline Bolton, Emaad Abdel-Rahman (2002). „Pimagedine: a novel therapy for diabetic nephropathy”. Expert Opinion on Investigational Drugs 11 (4): 565–574. DOI:10.1517/13543784.11.4.565. PMID 11922864. 

Spoljašnje veze

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