Chlorphenamine
Chlorphenamine ( chlorpheniramine, CP, හෝ CPM) යනු පළමු පරම්පරාවේ ප්රතිහිස්ටමින් (first-generation antihistamine) ඖෂධයකි.
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Systematic (IUPAC) name | |
3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine | |
Clinical data | |
Trade names | Chlor-Trimeton; Piriton |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682543 |
Pregnancy cat. | A (AU) B (US) |
Legal status | Pharmacist Only (S3) (AU) P (UK) OTC (US) |
Routes | By mouth, IV, IM, SC |
Pharmacokinetic data | |
Bioavailability | 25 to 50% |
Protein binding | 72% |
Metabolism | Hepatic (CYP2D6) |
Half-life | 13.9–43.4 hours[1] |
Excretion | Renal |
Identifiers | |
CAS number | 113-92-8 ![]() |
ATC code | R06AB04 |
PubChem | CID 2725 |
IUPHAR ligand | 1210 |
DrugBank | DB01114 |
ChemSpider | 2624 ![]() |
UNII | 3U6IO1965U ![]() |
KEGG | D07398 ![]() |
ChEBI | CHEBI:52010 ![]() |
ChEMBL | CHEMBL505 ![]() |
Chemical data | |
Formula | C16H19ClN2 |
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Physical data | |
Solubility in water | 0.55 g/100 mL, liquid mg/mL (20 °C) |
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මූලාශ්ර
සංස්කරණය- ^ Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL (1995). "Chlorpheniramine plasma concentration and histamine H1-receptor occupancy". Clin. Pharmacol. Ther. 58 (2): 210–20. doi:10.1016/0009-9236(95)90199-X. PMID 7648771.