Biperiden je organsko jedinjenje, koje sadrži 21 atom ugljenika i ima molekulsku masu od 311,461 Da.[1][2][3]

Biperiden
Klinički podaci
Prodajno imeAkineton, Akinophyl
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj514-65-8 ДаY
ATC kodN04AA02 (WHO)
PubChemCID 2381
DrugBankDB00810 ДаY
ChemSpider2289 ДаY
KEGGC07941 ДаY
ChEBICHEBI:3112 ДаY
ChEMBLCHEMBL1101 ДаY
Hemijski podaci
FormulaC21H29NO
Molarna masa311,461
  • OC(CCN1CCCCC1)(C1CC2CC1C=C2)C1=CC=CC=C1
  • InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2 ДаY
  • Key:YSXKPIUOCJLQIE-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja114 °C (237 °F)
Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 1
Broj rotacionih veza 5
Particioni koeficijent[4] (ALogP) 3,6
Rastvorljivost[5] (logS, log(mol/L)) -5,1
Polarna površina[6] (PSA, Å2) 23,5

Reference

уреди
  1. ^ Nishiyama K, Mizuno T, Sakuta M, Kurisaki H: Chronic dementia in Parkinson's disease treated by anticholinergic agents. Neuropsychological and neuroradiological examination. Adv Neurol. 1993;60:479-83. PMID 8420174
  2. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  3. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  4. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  5. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  6. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

уреди

Spoljašnje veze

уреди


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