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Amfiregulin

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Amfiregulin
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2RNL

Identifikatori
AliasiAREG
Vanjski ID-jeviOMIM: 104640 MGI: 88068 HomoloGene: 1252 GeneCards: AREG
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za Amfiregulin
Genomska lokacija za Amfiregulin
Bend4q13.3Početak74,445,136 bp[1]
Kraj74,455,005 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za Amfiregulin
Genomska lokacija za Amfiregulin
Bend5 E2|5 44.78 cMPočetak91,287,458 bp[2]
Kraj91,296,291 bp[2]
Ontologija gena
Molekularna funkcija cytokine activity
epidermal growth factor receptor binding
GO:0001948, GO:0016582 vezivanje za proteine
growth factor activity
Ćelijska komponenta citoplazma
integral component of membrane
endoplasmic reticulum membrane
membrana
intracellular anatomical structure
cell surface
ER to Golgi transport vesicle membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
jedro
Golđijeva membrana
Vanćelijsko
extracellular region
clathrin-coated vesicle membrane
Biološki proces dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
G protein-coupled receptor signaling pathway
response to estradiol
epidermal growth factor receptor signaling pathway
GO:1904578 response to organic cyclic compound
cell-cell signaling
mammary gland branching involved in thelarche
response to peptide hormone
response to glucocorticoid
mammary gland alveolus development
negative regulation of osteoblast differentiation
endoplasmic reticulum to Golgi vesicle-mediated transport
epithelial cell proliferation involved in mammary gland duct elongation
COPII vesicle coating
glial cell proliferation
response to cAMP
positive regulation of phosphorylation
Ćelijska proliferacija
neuron projection development
response to hydrogen peroxide
positive regulation of peptidyl-tyrosine phosphorylation
regulation of signaling receptor activity
positive regulation of cell population proliferation
MAPK cascade
GO:0072468 Transdukcija signala
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein kinase B signaling
membrane organization
positive regulation of keratinocyte proliferation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001657

NM_009704

RefSeq (bjelančevina)

NP_001648

NP_033834

Lokacija (UCSC)Chr 4: 74.45 – 74.46 MbChr 5: 91.29 – 91.3 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amfiregulin – poznat i kao AREG – je protein koji je kod ljudi kodiran iz gena pod oznakom AREG.[5][6][7]


Funkcija

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Protein koji je kodiran iz pomenutog gena je član porodice epidermskog faktora rasta (EGF).[5] To je jedan od autokrinih faktora rasta, kao i mitogen za astrocite, Schwannove ćelije, fibroblaste. Srodan je epidermskom faktoru rasta (EGF) i transformirajućem alfa faktoru rasta (TGF-alfa). Ovaj proteinThis je u međudjejstvu sa receptorom epidermskog faktora rasta (EGFR) u promociji rasta normalnih epitelnih ćelija.[8][9][10]

Biološka uloga

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Estradiol i progesteron glavninom podstiču ekspresiju amfiregulina u posredovanju kanala u razvoju mliječnih žlijezda.[11][12][13][14][15] Nađeno je da je amfiregulin suštinski bitan za razvoj mliječnih kanala, koji nije prisutan kod razvoja mliječnih kanalića u amfiregulinski knockout miša.[14] Sličan je fenotipovima EGFR i estrogenskom receptoru alfa (ERα) knockout miša, koji također ispoljava odsustvo duktalnog rasta.[14]

Klinički značaj

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Mutacije u kodiranom proteinu su vezane sa psorijazi sličnom fenotipu kože.[5]

Također pogledajte

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Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109321 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029378 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: AREG amphiregulin (schwannoma-derived growth factor)".
  6. ^ Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ (februar 1989). "Structure and function of human amphiregulin: a member of the epidermal growth factor family". Science. 243 (4894 Pt 1): 1074–6. doi:10.1126/science.2466334. PMID 2466334.CS1 održavanje: više imena: authors list (link)
  7. ^ Plowman GD, Green JM, McDonald VL, Neubauer MG, Disteche CM, Todaro GJ, Shoyab M (maj 1990). "The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity". Mol. Cell. Biol. 10 (5): 1969–81. PMC 360543. PMID 2325643. Arhivirano s originala, 24. 5. 2011. Pristupljeno 28. 1. 2016.CS1 održavanje: više imena: authors list (link)
  8. ^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
  9. ^ Nelson D. L., Cox M. M. (2013): Lehninger Principles of Biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.
  10. ^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
  11. ^ Aupperlee MD, Leipprandt JR, Bennett JM, Schwartz RC, Haslam SZ (2013). "Amphiregulin mediates progesterone-induced mammary ductal development during puberty". Breast Cancer Res. 15 (3): R44. doi:10.1186/bcr3431. PMC 3738150. PMID 23705924.
  12. ^ LaMarca HL, Rosen JM (2007). "Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage". Breast Cancer Res. 9 (4): 304. doi:10.1186/bcr1740. PMC 2206713. PMID 17659070.
  13. ^ Kariagina A, Xie J, Leipprandt JR, Haslam SZ (2010). "Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers". Horm Cancer. 1 (5): 229–44. doi:10.1007/s12672-010-0048-0. PMC 3000471. PMID 21258428.
  14. ^ a b c McBryan J, Howlin J, Napoletano S, Martin F (2008). "Amphiregulin: role in mammary gland development and breast cancer". J Mammary Gland Biol Neoplasia. 13 (2): 159–69. doi:10.1007/s10911-008-9075-7. PMID 18398673.
  15. ^ Sternlicht MD, Sunnarborg SW (2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". J Mammary Gland Biol Neoplasia. 13 (2): 181–94. doi:10.1007/s10911-008-9084-6. PMC 2723838. PMID 18470483.

Dopunska literatura

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