File:Iron BBB.jpg
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![File:Iron BBB.jpg](http://178.128.105.246/cars-https-upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Iron_BBB.jpg/455px-Iron_BBB.jpg?20240130233713)
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Intracerebral metabolism of iron and its neuro‐bioavailability.
Summary
[edit]DescriptionIron BBB.jpg |
English: Iron crosses the blood–brain barrier (BBB) either by:
• The transcytosis pathway, where the complex “diferric Fe3+-transferrin-transferrin receptor 1 (TfR1)” undergoes endocytosis and exocytosis from the luminal pole to the cerebral extracellular matrix (ECM) and interstitial fluid. • The facilitated transporter pathway, where endothelial cells internalize the complex “diferric Fe3+-transferrin-transferrin receptor 1 (TfR1)” in endosome, reduce ferric Fe3+ ion to ferrous Fe2+ ion by STEAP3 enzyme and then Fe2+ ion crosses the endosomal membrane thanks to DMT1. Fer²+ is then exported to the extracellular matrix (ECM) and interstitial fluid, via ferroportin coupled with ceruloplasmin (Note that transferrin is not only a plasmatic protein and choroid plexuses can secrete it). |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175715/ |
Author | Christian Berthou, Jean Paul Iliou, and Denis Barba |
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current | 23:37, 30 January 2024 | ![]() | 700 × 923 (165 KB) | PecMo (talk | contribs) | Uploaded a work by Christian Berthou, Jean Paul Iliou, and Denis Barba from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175715/ with UploadWizard |
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