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Chemical compound
Uldazepam Other names 7-chloro-5-(2-chlorophenyl)-N -prop-2-enoxy-3H -1,4-benzodiazepin-2-amine ATC code
(2Z )-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2H -1,4-benzodiazepin-2-one O -allyloxime
CAS Number PubChem CID ChemSpider UNII KEGG CompTox Dashboard (EPA ) Formula C 18 H 15 Cl 2 N 3 O Molar mass 360.24 g·mol−1 3D model (JSmol )
Clc3ccccc3C/2=N/CC(=N/c1c\2cc(Cl)cc1)\NOC\C=C
InChI=1S/C18H15Cl2N3O/c1-2-9-24-23-17-11-21-18(13-5-3-4-6-15(13)20)14-10-12(19)7-8-16(14)22-17/h2-8,10H,1,9,11H2,(H,22,23)
Y Key:DTMPGSXFUXZBDK-UHFFFAOYSA-N
Y
N Y (what is this?) (verify)
Uldazepam is a drug which is a benzodiazepine derivative.[ 1] It has sedative and anxiolytic effects similar to those of other benzodiazepines.[ 2] [ 3]
Synthesis
Thio thionamide is even more prone to amidine formation than the lactam itself.
Uldazepam synthesis:[ 4] J. B. Hester, Jr., (1970); Chem. Abstr., 73: 99,001t (1970).
Reaction of thionamide (2 ) with O -allyl-hydroxylamine gave the oximino (3 ) uldazepam.
See also
References
^ "Uldazepam U 31920" . Psychotropics. Retrieved 12 June 2013 .
^ Oelschläger H, Ellaithy MM, Volke J (February 1988). "[Mechanism of the polarographic reduction of the tranquilizer uldazepam]". Archiv der Pharmazie (in German). 321 (2): 69–72. doi :10.1002/ardp.19883210205 . PMID 3369929 . S2CID 96356746 .
^ Itil TM, Akpinar S, Ozkut H, Balki N, Herrmann WM (June 1974). "Clinical and computerized EEG effects of U-31,920, a new anxiolytic". Current Therapeutic Research, Clinical and Experimental . 16 (6): 642–54. PMID 4211146 .
^ DE 2005176 , Hester Jr., Jackson Boling, "3H-1,4-benzodiazepine und Verfahren zu deren Herstellung [3H-1,4-benzodiazepines and processes for their preparation]", published 1970-09-10, assigned to The Upjohn Co.
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