Anti-actin antibodies
Anti-actin antibodies (AAA)[1] are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.
In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage.[2][3]
In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition,[4] the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients.[5]
In gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.[6]
It has also been found as a paraneoplastic syndrome with myelodysplastic syndrome.[7]
References
- ^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 978-0-397-54589-6.
- ^ Pedreira S, Sugai E, Moreno ML, et al. (2005). "Significance of smooth muscle/anti-actin autoantibodies in celiac disease". Acta Gastroenterol. Latinoam. 35 (2): 83–93. PMID 16127984.
- ^ Carroccio A, Brusca I, Iacono G, et al. (2007). "IgA anti-actin antibodies ELISA in coeliac disease: A multicentre study" (PDF). Digestive and Liver Disease. 39 (9): 818–23. doi:10.1016/j.dld.2007.06.004. hdl:10447/34417. PMID 17652043.
- ^ Muratori P, Muratori L, Agostinelli D, et al. (2002). "Smooth muscle antibodies and type 1 autoimmune hepatitis". Autoimmunity. 35 (8): 497–500. doi:10.1080/0891693021000054066. PMID 12765475.
- ^ Ballot E, Homberg JC, Johanet C (2000). "Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis". J. Hepatol. 33 (2): 208–15. doi:10.1016/S0168-8278(00)80361-X. PMID 10952238.
- ^ Konstandoulakis MM, Syrigos KN, Leandros M, Charalabopoulos A, Manouras A, Golematis BC (1998). "Autoantibodies in the serum of patients with gastric cancer: their prognostic importance". Hybridoma. 17 (5): 431–5. doi:10.1089/hyb.1998.17.431. PMID 9873988.
- ^ Enright, Helen (Oct 1995). "Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: response to immunosuppressive therapy". British Journal of Haematology. 91 (2): 403–8. doi:10.1111/j.1365-2141.1995.tb05310.x. PMID 8547082.