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ADH1A

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ADH1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH1A, ADH1, alcohol dehydrogenase 1A (class I), alpha polypeptide
External IDsOMIM: 103700; MGI: 87921; HomoloGene: 88335; GeneCards: ADH1A; OMA:ADH1A - orthologs
EC number1.1.1.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000667

NM_007409

RefSeq (protein)

NP_000658

NP_031435

Location (UCSC)Chr 4: 99.28 – 99.29 MbChr 3: 137.97 – 138 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene.[5][6]

This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187758Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074207Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith M (Mar 1986). "Genetics of Human Alcohol and Aldehyde Dehydrogenases". Advances in Human Genetics vol. 15. Vol. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456.
  6. ^ a b "Entrez Gene: ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide".

Further reading

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