Control of HIV-1 replication in elite suppressors
- PMID: 20350494
Control of HIV-1 replication in elite suppressors
Abstract
HIV-1 infection usually results in high level of viral replication leading to a progressive decline of CD4+ T cells and eventually to full blown AIDS. Long term non-progressors (LTNPs) are patients who have stable CD4 counts for more than 5 years without antiretroviral therapy. Most of these patients have detectable levels of viremia and eventually will progress to AIDS. Elite controllers or suppressors (ES) represent a distinct subset of untreated patients who appear to be able to completely control viral replication. These patients maintain viral loads below the limit of detection of commercial assays for many years and generally do not show any clinical signs of disease progression. The mechanisms responsible for this remarkable control may lead to the design of effective HIV-1 vaccines.
Similar articles
-
Elucidating the elite: mechanisms of control in HIV-1 infection.Trends Pharmacol Sci. 2009 Dec;30(12):631-7. doi: 10.1016/j.tips.2009.09.005. Trends Pharmacol Sci. 2009. PMID: 19837464 Review.
-
HIV controllers: how do they tame the virus?Trends Immunol. 2007 Dec;28(12):532-40. doi: 10.1016/j.it.2007.09.002. Epub 2007 Nov 5. Trends Immunol. 2007. PMID: 17981085 Review.
-
Immune activation and antibody responses in non-progressing elite controller individuals infected with HIV-1.J Med Virol. 2009 Oct;81(10):1681-90. doi: 10.1002/jmv.21565. J Med Virol. 2009. PMID: 19697415
-
HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation.Antivir Ther. 2007;12(6):971-5. Antivir Ther. 2007. PMID: 17926652
-
[HIV controllers: a homogeneous group of HIV-1 infected patients with a spontaneous control of viral replication].Pathol Biol (Paris). 2006 Dec;54(10):566-71. doi: 10.1016/j.patbio.2006.07.035. Epub 2006 Oct 5. Pathol Biol (Paris). 2006. PMID: 17027185 French.
Cited by
-
Sex differences in HIV-1 persistence and the implications for a cure.Front Glob Womens Health. 2022 Sep 23;3:942345. doi: 10.3389/fgwh.2022.942345. eCollection 2022. Front Glob Womens Health. 2022. PMID: 36212905 Free PMC article. Review.
-
Contribution of the HIV-1 Envelope Glycoprotein to AIDS Pathogenesis and Clinical Progression.Biomedicines. 2022 Sep 2;10(9):2172. doi: 10.3390/biomedicines10092172. Biomedicines. 2022. PMID: 36140273 Free PMC article. Review.
-
Predicting the HIV/AIDS epidemic and measuring the effect of AIDS Conquering Project in Guangxi Zhuang Autonomous Region.PLoS One. 2022 Jul 1;17(7):e0270525. doi: 10.1371/journal.pone.0270525. eCollection 2022. PLoS One. 2022. PMID: 35776707 Free PMC article.
-
Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control.Front Immunol. 2022 May 20;13:879124. doi: 10.3389/fimmu.2022.879124. eCollection 2022. Front Immunol. 2022. PMID: 35720328 Free PMC article. Review.
-
CD8 Effector T Cells Function Synergistically With Broadly Neutralizing Antibodies to Enhance Suppression of HIV Infection.Front Immunol. 2021 Jul 29;12:708355. doi: 10.3389/fimmu.2021.708355. eCollection 2021. Front Immunol. 2021. PMID: 34394110 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials