Human endogenous retroviruses: transposable elements with potential?
- PMID: 15373898
- PMCID: PMC1809191
- DOI: 10.1111/j.1365-2249.2004.02592.x
Human endogenous retroviruses: transposable elements with potential?
Abstract
Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.
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References
-
- Knipe DM, Howley PM. Fields virology. 4. Philadelphia USA: Lippincott, Williams & Wilkins; 2001.
-
- Pennisi E. Gene counters struggle to get the right answer. Science. 2003;301:1040–1. - PubMed
-
- International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921. - PubMed
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