Immune evasion by staphylococci
- PMID: 16322743
- DOI: 10.1038/nrmicro1289
Immune evasion by staphylococci
Abstract
Staphylococcus aureus can cause superficial skin infections and, occasionally, deep-seated infections that entail spread through the blood stream. The organism expresses several factors that compromise the effectiveness of neutrophils and macrophages, the first line of defence against infection. S. aureus secretes proteins that inhibit complement activation and neutrophil chemotaxis or that lyse neutrophils, neutralizes antimicrobial defensin peptides, and its cell surface is modified to reduce their effectiveness. The organism can survive in phagosomes, express polysaccharides and proteins that inhibit opsonization by antibody and complement, and its cell wall is resistant to lysozyme. Furthermore, S. aureus expresses several types of superantigen that corrupt the normal humoral immune response, resulting in anergy and immunosuppression. In contrast, Staphylococcus epidermidis must rely primarily on cell-surface polymers and the ability to form a biolfilm to survive in the host.
Similar articles
-
Bacterial evasion of innate host defenses--the Staphylococcus aureus lesson.Int J Med Microbiol. 2004 Sep;294(2-3):189-94. doi: 10.1016/j.ijmm.2004.06.016. Int J Med Microbiol. 2004. PMID: 15493829 Review.
-
Staphylococcal cutaneous infections: invasion, evasion and aggression.J Dermatol Sci. 2006 Jun;42(3):203-14. doi: 10.1016/j.jdermsci.2006.03.011. Epub 2006 May 6. J Dermatol Sci. 2006. PMID: 16679003 Review.
-
Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection.Cell Rep. 2021 Jul 27;36(4):109462. doi: 10.1016/j.celrep.2021.109462. Cell Rep. 2021. PMID: 34320352 Free PMC article.
-
Staphylococcus epidermidis strategies to avoid killing by human neutrophils.PLoS Pathog. 2010 Oct 7;6(10):e1001133. doi: 10.1371/journal.ppat.1001133. PLoS Pathog. 2010. PMID: 20949069 Free PMC article.
-
Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus.Front Cell Infect Microbiol. 2017 Jun 30;7:286. doi: 10.3389/fcimb.2017.00286. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28713774 Free PMC article. Review.
Cited by
-
Phage display for the detection, analysis, disinfection, and prevention of Staphylococcus aureus.Smart Med. 2022 Dec 23;1(1):e20220015. doi: 10.1002/SMMD.20220015. eCollection 2022 Dec. Smart Med. 2022. PMID: 39188734 Free PMC article. Review.
-
Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection.Nat Microbiol. 2024 Aug 12. doi: 10.1038/s41564-024-01769-9. Online ahead of print. Nat Microbiol. 2024. PMID: 39134708
-
Elucidating the potential of isorhapontigenin in targeting the MgrA regulatory network: a paradigm shift for attenuating MRSA virulence.Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0061124. doi: 10.1128/aac.00611-24. Epub 2024 Jul 24. Antimicrob Agents Chemother. 2024. PMID: 39046236
-
Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein.mBio. 2024 Aug 14;15(8):e0151224. doi: 10.1128/mbio.01512-24. Epub 2024 Jul 22. mBio. 2024. PMID: 39037275 Free PMC article.
-
A highly neutralizing human monoclonal antibody targeting a novel linear epitope on staphylococcal enterotoxin B.Hum Vaccin Immunother. 2024 Dec 31;20(1):2360338. doi: 10.1080/21645515.2024.2360338. Epub 2024 Jun 10. Hum Vaccin Immunother. 2024. PMID: 38857905 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical