Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Jul 3;5(2):28-9.
doi: 10.4081/hr.2013.e8. Print 2013 Jun 28.

A case report of acute myeloid leukemia and neurofibromatosis 1

Chiara Sartor  1 , Cristina Papayannidis, Maria Chiara Abbenante, Antonio Curti, Nicola Polverelli, Emanuela Ottaviani, Ilaria Iacobucci, Viviana Guadagnuolo, Giovanni Martinelli
Affiliations
Case Reports

A case report of acute myeloid leukemia and neurofibromatosis 1

Chiara Sartor et al. Hematol Rep. .

Abstract

We report a case of a 65-year old patient affected by neurofibromatosis 1, documented by the presence of germ-line mutation on the NF1 gene, who developed various hyperproliferative malignant and benign diseases. He was brought to our attention for the diagnosis of acute myeloid leukemia revealed by major fatigue and dyspnea. The disease characteristics at diagnosis were hyperleukocytosis and complex karyotype with the inversion of the chromosome 16, classifying as a high-risk leukemia. The association between leukemia and neurofibromatosis 1 is controversial and needs to be further investigated. Nevertheless, such patients present a wide number of comorbidities that make therapeutic strategies most difficult.

Keywords: NF1; Von Recklinghausen disease; acute myeloid leukemia; neurofibromatosis type 1,.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Neurofibromatosis type I and multiple myeloma coexistence: A possible link?
    Accardi F, Marchica V, Mancini C, Maredi E, Racano C, Notarfranchi L, Martorana D, Storti P, Martella E, Palma BD, Craviotto L, Filippo M, Percesepe A, Aversa F, Giuliani N. Accardi F, et al. Hematol Rep. 2018 Apr 3;10(1):7457. doi: 10.4081/hr.2018.7457. eCollection 2018 Mar 2. Hematol Rep. 2018. PMID: 29721253 Free PMC article.

References

    1. Littler M, Morton NE.Segregation analysis of peripheral neurofibromatosis (NF1). J Med Genet 1990;27:307-10 - PMC - PubMed
    1. Boyd KP, Korf BR, Theos A.Neurofibro - matosis type 1. J Am Acad Dermatol 2009; 61:1-14 - PMC - PubMed
    1. Yohay K.Neurofibromatosis type 1 and associated malignancies. Curr Neurol Neurosci Rep 2009;9:247-53 - PubMed
    1. Walker L, Thompson D, Easton D, et al. A prospective study of neurofibromatosis type 1 cancer incidence in the UK. Br J Cancer 2006;95:233-8 - PMC - PubMed
    1. Williams VC, Lucas J, Babcock MA, et al. Neurofibromatosis type 1 revisited. Pediatrics 2009;123:124-33 - PubMed

Publication types

LinkOut - more resources