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Review
. 2014 Jun;20(6):485-95.
doi: 10.1111/cns.12270. Epub 2014 Apr 10.

Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease

Marco Miroddi  1 , Michele Navarra, Maria C Quattropani, Fabrizio Calapai, Sebastiano Gangemi, Gioacchino Calapai
Affiliations
Review

Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease

Marco Miroddi et al. CNS Neurosci Ther. 2014 Jun.

Abstract

Salvia officinalis L. and Salvia lavandulaefolia L. have a longstanding use as traditional herbal remedies that can enhance memory and improve cognitive functions. Pharmacological actions of S. officinalis and S. lavandulaefolia on healthy subjects and on patients suffering of cognitive decline have been investigated. Aim of this review was to summarize published clinical trials assessing effectiveness and safety of S. officinalis and S. lavandulaefolia in the enhancement of cognitive performance in healthy subjects and neurodegenerative illnesses. Furthermore, to purchase a more complete view on safety of S. officinalis and S. lavandulaefolia, we collected and discussed articles regarding toxicity and adverse reactions. Eight clinical studies investigating on acute effects of S. officinalis on healthy subjects were included in the review. Six studies investigated on the effects of S. officinalis and S. lavandaeluaefolia on cognitive performance in healthy subjects. The two remaining were carried out to study the effects of sage on Azheimer's disease. Our review shows that S. officinalis and S. lavandulaefolia exert beneficial effects by enhancing cognitive performance both in healthy subjects and patients with dementia or cognitive impairment and is safe for this indication. Unfortunately, promising beneficial effects are debased by methodological issues, use of different herbal preparations (extracts, essential oil, use of raw material), lack of details on herbal products used. We believe that sage promising effects need further higher methodological standard clinical trials.

Keywords: Alzheimer's disease; Cognitive impairment; Memory; Salvia lavandulaefolia; Salvia officinalis.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine: Expanded commission E monographs. Boston, MA: American Botanical Council, 2000.
    1. Barnes J, Phillipson DJ. Sage. Herbal medicines, 3rd edn London: The Pharmaceutical Press, 2007.
    1. Clebsch B. The new book of salvias: Sages for every garden. Portland, OR: Timber Press, 2008.
    1. Tildesley N, Kennedy D, Perry E, et al. Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav 2003;75:669–674. - PubMed
    1. DeFina PA, Moser RS, Glenn M, Lichtenstein JD, Fellus J. Alzheimer's disease clinical and research update for health care practitioners. J Aging Res 2013;2013:207178. - PMC - PubMed

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