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Review
. 2017 Apr 28:11:53-62.
doi: 10.2174/1874285801711010053. eCollection 2017.

Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents

Shriti Singh  1 , Santosh Kumar Singh  2 , Indrajit Chowdhury  3 , Rajesh Singh  2
Affiliations
Review

Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents

Shriti Singh et al. Open Microbiol J. .

Abstract

A biofilm is a group of microorganisms, that causes health problems for the patients with indwelling medical devices via attachment of cells to the surface matrix. It increases the resistance of a microorganism for antimicrobial agents and developed the human infection. Current strategies are removed or prevent the microbial colonies from the medical devices, which are attached to the surfaces. This will improve the clinical outcomes in favor of the patients suffering from serious infectious diseases. Moreover, the identification and inhibition of genes, which have the major role in biofilm formation, could be the effective approach for health care systems. In a current review article, we are highlighting the biofilm matrix and molecular mechanism of antimicrobial resistance in bacterial biofilms.

Keywords: Biofilm; Efflux pump; Heterogeneity; Quorum sensing; Resistance.

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Figures

Fig. (1)
Fig. (1)
Mechanisms of resistance in bacterial biofilm.
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