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. 2018 Mar 21:18:4.
doi: 10.1186/s12901-018-0052-5. eCollection 2018.

Treatment, outcomes, and demographics in sinonasal sarcoma: a systematic review of the literature

Mitchell R Gore  1
Affiliations

Treatment, outcomes, and demographics in sinonasal sarcoma: a systematic review of the literature

Mitchell R Gore. BMC Ear Nose Throat Disord. .

Abstract

Background: Sarcomas comprise a diverse group of soft tissue mesenchymal malignancies. The sinuses and nasal region are a relatively rare site of sarcomas.

Methods: Retrospective review of the literature on sinonasal sarcomas from 1987-2017. Data were analyzed for demographics, treatment type, stage, and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival.

Results: A total of 198 cases of sinonasal sarcoma were identified and analyzed. The median age at diagnosis was 39 years. Overall 5-, 10-, and 20-year survival was 61.3%, 58.9%, and 49.1%, respectively, and disease-free 5-, 10-, and 20-year survival was 53.2%, 49.1%, and 38.3%, respectively. Lymph node metastasis was present at diagnosis in 3.0% of cases, and distant metastasis was present in 3.5% of cases. On univariate analysis T stage, overall stage, treatment type, histopathologic subtype, and presence of distant metastasis significantly affected survival. On multivariate analysis overall stage alone significantly predicted overall survival. Open vs. endoscopic surgery, total radiation dose, and presence of neck metastasis did not significantly affect survival. Combined modality treatment was associated with higher survival rates than single modality therapy.

Conclusions: Sinonasal sarcoma is a relatively rare malignancy. Lower T and overall stage, lack of distant metastasis, and multimodality therapy were associated with improved survival. Certain histopathologic subtypes were associated with poorer survival.

Keywords: Endoscopic; Kaplan-Meier; Sinonasal cancer; Sinonasal sarcoma; Survival.

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Conflict of interest statement

Not applicable.Not applicable.The author declares that he has no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
PRISMA diagram illustrating the methods for study selection
Fig. 2
Fig. 2
Kaplan-Meier overall survival for all patients
Fig. 3
Fig. 3
Kaplan Meier disease-free survival for all patients
Fig. 4
Fig. 4
a Kaplan-Meier overall survival by stage. b Kaplan-Meier disease-free survival by stage
Fig. 5
Fig. 5
a Kaplan-Meier overall survival by tumor (T) stage. b Kaplan-Meier disease-free survival by tumor (T) stage
Fig. 6
Fig. 6
a Kaplan-Meier overall survival by tumor grade (G). b Kaplan-Meier disease-free survival by tumor grade (G)
Fig. 7
Fig. 7
a Kaplan-Meier overall survival by total radiation dose. b Kaplan-Meier disease-free survival by total radiation dose
Fig. 8
Fig. 8
a Kaplan-Meier overall survival by metastasis (M) stage. b Kaplan-Meier disease-free survival by metastasis (M) stage
Fig. 9
Fig. 9
a. Kaplan-Meier overall survival by neck (N) stage. b Kaplan-Meier disease-free survival by neck (N) stage
Fig. 10
Fig. 10
a Kaplan-Meier overall survival by treatment modality. b Kaplan-Meier disease-free survival by treatment modality
Fig. 11
Fig. 11
a Kaplan-Meier overall survival by tumor type. b Kaplan-Meier disease-free survival by tumor type
Fig. 12
Fig. 12
a Kaplan-Meier overall survival by type of surgery. b Kaplan-Meier disease-free survival by type of surgery
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