GNA：修订间差异
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Datou 1996（留言 | 贡献） // Edit via Wikiplus |
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== 參考文獻 == |
== 參考文獻 == |
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*{{cite journal en|author=Zhang Lilu, Peritz Adam, Meggers Eric |title=A simple glycol nucleic acid |journal=J Am Chem Soc |volume=127 |issue=12 |pages=4174-5 |year=2005 |url=http://www.sas.upenn.edu/~meggers/pdf/JACS2005_2.pdf |pmid=15783191}} |
*{{cite journal en|author=Zhang Lilu, Peritz Adam, Meggers Eric |title=A simple glycol nucleic acid |journal=J Am Chem Soc |volume=127 |issue=12 |pages=4174-5 |year=2005 |url=http://www.sas.upenn.edu/~meggers/pdf/JACS2005_2.pdf |pmid=15783191}} |
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*Seita, Tooru; Yamauchi, Kiyoshi; Kinoshita, Masayoshi; Imoto, Minoru. Condensation polymerization of nucleotide analogues. Die Makromolekulare Chemie (1972), 154:255-261. |
*Seita, Tooru; Yamauchi, Kiyoshi; Kinoshita, Masayoshi; Imoto, Minoru. Condensation polymerization of nucleotide analogues. Die Makromolekulare Chemie (1972), 154:255-261. |
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*Ueda, Nasuo; Kawabata, Toshio; Takemoto, Kiichi. Synthesis of N-(2,3-dihydroxypropyl) derivatives of nucleic bases. Journal of Heterocyclic Chemistry (1971), 8(5), 827-9. |
*Ueda, Nasuo; Kawabata, Toshio; Takemoto, Kiichi. Synthesis of N-(2,3-dihydroxypropyl) derivatives of nucleic bases. Journal of Heterocyclic Chemistry (1971), 8(5), 827-9. |
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== 外部連結 == |
== 外部連結 == |
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*[http://www.sas.upenn.edu/~meggers/research/GNA.html Meggers Laboratory] |
*[http://www.sas.upenn.edu/~meggers/research/GNA.html Meggers Laboratory] |
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*[http://pubs.acs.org/cen/news/83/i12/8312notw8.html Simpler than DNA] - Chemical and engineering news |
*[http://pubs.acs.org/cen/news/83/i12/8312notw8.html Simpler than DNA] - Chemical and engineering news |
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2017年9月5日 (二) 01:50的版本
GNA全名Glycerol nucleic acid，中文直譯甘油核酸。是一種與DNA或RNA相似的化學物質，但組成物有所不同。並不存在任何目前已知的自然界生物體內。
GNA的骨架是由許多重複的甘油（DNA與RNA為五碳糖）經由磷酸酯鍵的連結所組成。雖然甘油分子只有3個碳原子，但GNA仍然可比表現出沃森-克里克鹼基配對（A對T；G對C），而且比起DNA與RNA，GNA的鹼基配對更為穩定，需要較高的融解溫度（Tm）才能解開。
參考文獻
- Zhang Lilu, Peritz Adam, Meggers Eric. A simple glycol nucleic acid (PDF). J Am Chem Soc. 2005, 127 (12): 4174–5. PMID 15783191. （原始内容 (PDF)存档于2007-01-06）.
- Seita, Tooru; Yamauchi, Kiyoshi; Kinoshita, Masayoshi; Imoto, Minoru. Condensation polymerization of nucleotide analogues. Die Makromolekulare Chemie (1972), 154:255-261.
- Ueda, Nasuo; Kawabata, Toshio; Takemoto, Kiichi. Synthesis of N-(2,3-dihydroxypropyl) derivatives of nucleic bases. Journal of Heterocyclic Chemistry (1971), 8(5), 827-9.
- Acevedo, Oscar L.; Andrews, Robert S. Synthesis of propane-2,3-diol combinatorial monomers. Tetrahedron Letters (1996), 37(23), 3931-3934.
- Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Synthesis of acyclic oligonucleotides as antiviral and antiinflammatory agents and inhibitors of phospholipase A2. PCT Int. Appl. (1995), 126 pp. WO 9518820 A1 19950713 CAN 124:30276 AN 1995:982328
- Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Preparation of ethylene glycol phosphate linked oligodeoxyribonucleotides as phospholipase A2 inhibitors. U.S. (1999), 39 pp., Cont.-in-part of U.S. Ser. No. 179,970. CODEN: USXXAM US 5886177 A 19990323 CAN 130:237811 AN 1999:205354
外部連結
- Meggers Laboratory
- Simpler than DNA - Chemical and engineering news
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