CCL12(英語:Chemokine (C-C motif) ligand 12)是一個小型的細胞因子,屬於CC趨化因子家族,最早在鼠類中發現。它還被叫做單核細胞趨化蛋白5(英語:monocyte chemotactic protein 5,MCP-5),又由於其和人類趨化因子MCP-1的相似性,有時候也被稱為MCP-1相關趨化因子(英語:MCP-1-related chemokine)。CCL12特異性影響嗜酸性粒細胞、單核細胞和淋巴細胞[1]。這個趨化因子正常情況下存在於淋巴結和胸腺中,其表達能顯著誘導巨噬細胞[1][2]。編碼CCL12的基因發現於小鼠染色體11上[2]。
- ^ 1.0 1.1 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996, 184 (5): 1939–51. PMC 2192876 . PMID 8920881. doi:10.1084/jem.184.5.1939.
- ^ 2.0 2.1 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997, 185 (1): 99–109. PMC 2196097 . PMID 8996246. doi:10.1084/jem.185.1.99.