Katalitska podjedinica kalpaina-1 (CANP 1) jest protein koji je kod ljudi kodiran genom CAPN1 sa hromosoma 11.[5][6][7]

Kalpain-1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1ZCM, 2ARY

Identifikatori
AliasiCAPN1
Vanjski ID-jeviOMIM: 114220 MGI: 88263 HomoloGene: 3800 GeneCards: CAPN1
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za Kalpain-1
Genomska lokacija za Kalpain-1
Bend11q13.1Početak65,180,566 bp[1]
Kraj65,212,006 bp[1]
Lokacija gena (miš)
Hromosom 19 (miš)
Hrom.Hromosom 19 (miš)[2]
Hromosom 19 (miš)
Genomska lokacija za Kalpain-1
Genomska lokacija za Kalpain-1
Bend19 A|19 4.34 cMPočetak6,038,573 bp[2]
Kraj6,065,927 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija cysteine-type peptidase activity
vezivanje iona metala
GO:0070122 peptidase activity
GO:0001948, GO:0016582 vezivanje za proteine
hydrolase activity
endopeptidase activity
calcium ion binding
calcium-dependent cysteine-type endopeptidase activity
Ćelijska komponenta membrana
focal adhesion
intracellular anatomical structure
mitohondrija
Lizozom
Egzosom
citosol
extracellular region
citoplazma
ćelijska membrana
ficolin-1-rich granule lumen
Biološki proces extracellular matrix disassembly
receptor catabolic process
positive regulation of cell population proliferation
regulation of macroautophagy
mammary gland involution
neutrophil degranulation
GO:0048552 regulation of catalytic activity
cornification
self proteolysis
Proteoliza
regulation of NMDA receptor activity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001198868
NM_001198869
NM_005186

NM_001110504
NM_007600

RefSeq (bjelančevina)

NP_001185797
NP_001185798
NP_005177

NP_001103974
NP_031626

Lokacija (UCSC)Chr 11: 65.18 – 65.21 MbChr 19: 6.04 – 6.07 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš


Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 714 aminokiselina, a molekulska težina 81.890 Da.[7]

1020304050
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCL
QSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVD
GATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFH
FQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNG
SYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGC
SIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEI
CNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR
LDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPST
FEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKAL
FRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFK
LNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVV
TFDLFKWLQLTMFA

Funkcija

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Kalpaini, neutralne proteaze aktivirane kalcijem, su nelizozomalne, unutarćelijskee cisteinskr proteaze. Kalpaini sisara uključuju sveprisutne proteine specifične za želudac i mišiće. Sveprisutni enzimi se sastoje od heterodimera s različitim velikim, katalitskim podjedinicama povezanim sa zajedničkom malom, regulatornom podjedinicom. Ovaj gen kodira veliku podjedinicu sveprisutnog enzima, kalpain-1.[7]

Interakcije

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Pokazalo se da CAPN1 reaguje sa PSEN2.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000014216 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024942 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aoki K, Imajoh S, Ohno S, Emori Y, Koike M, Kosaki G, Suzuki K (Oct 1986). "Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence". FEBS Lett. 205 (2): 313–7. doi:10.1016/0014-5793(86)80919-X. PMID 3017764. S2CID 36697759.
  6. ^ Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K (Nov 1990). "Four genes for the calpain family locate on four distinct human chromosomes". Cytogenet Cell Genet. 53 (4): 225–9. doi:10.1159/000132937. PMID 2209092.
  7. ^ a b c "Entrez Gene: CAPN1 calpain 1, (mu/I) large subunit".
  8. ^ Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K (1998). "The presenilin 2 loop domain interacts with the mu-calpain C-terminal region". Int. J. Mol. Med. 1 (5): 797–9. doi:10.3892/ijmm.1.5.797. PMID 9852298.

Dopunska literatuta

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Vanjski linkovi

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