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Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Voss R, Lerer I, Povey S, Solomon E, Bobrow M (Jul 1980). "Confirmation and further regional assignment of aminoacylase 1 (acy-1) on human chromosome 3 using a simplified detection method". Annals of Human Genetics. 44 (Pt 1): 1–9. doi:10.1111/j.1469-1809.1980.tb00940.x. PMID6948533. S2CID21566170.
Mitta M, Kato I, Tsunasawa S (Aug 1993). "The nucleotide sequence of human aminoacylase-1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (2): 201–3. doi:10.1016/0167-4781(93)90116-u. PMID8357837.
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Van Coster RN, Gerlo EA, Giardina TG, Engelke UF, Smet JE, De Praeter CM, Meersschaut VA, De Meirleir LJ, Seneca SH, Devreese B, Leroy JG, Herga S, Perrier JP, Wevers RA, Lissens W (Dec 2005). "Aminoacylase I deficiency: a novel inborn error of metabolism". Biochemical and Biophysical Research Communications. 338 (3): 1322–1326. doi:10.1016/j.bbrc.2005.10.126. PMID16274666.
Figueiredo EL, Garcia Leão FV, De Oliveira LV, Moreira Mda C, De Souza Figueiredo AF (Oct 2006). "The amidase activity of human tissue kallikrein is significantly lower in the urine of patients with systolic heart failure". Journal of Cardiac Failure. 12 (8): 653–658. doi:10.1016/j.cardfail.2006.06.004. PMID17045186.