Jump to content

Outer membrane efflux protein

From Wikipedia, the free encyclopedia
(Redirected from TolB)
Outer membrane efflux protein
Identifiers
SymbolOEP
PfamPF02321
InterProIPR003423
SCOP21ek9 / SCOPe / SUPFAM
TCDB1.B.17
OPM superfamily34
OPM protein1yc9
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The outer membrane efflux protein is a protein family member that forms trimeric (three-piece) channels allowing the export of a variety of substrates in gram-negative bacteria. Each efflux protein is composed of two repeats. The trimeric channel is composed of a 12-stranded beta-barrel that spans the outer membrane, and a long tail helical barrel that spans the periplasm.

Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.

References

[edit]
  • Johnson JM, Church GM (April 1999). "Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps". Journal of Molecular Biology. 287 (3): 695–715. CiteSeerX 10.1.1.73.559. doi:10.1006/jmbi.1999.2630. PMID 10092468.