We're excited to highlight a recent paper in the European Heart Journal on the genetics of hypertrophic cardiomyopathy (HCM). The study reveals that pathogenic variations in cardiac sarcomere genes account for 30%-40% of HCM cases. This paper speaks to the importance of genetic testing to understand the underlying cause of the disease, diagnostic confirmation, and future family planning. Discover more here: https://lnkd.in/gw8Y7ZWn
Lexeo Therapeutics
Biotechnology Research
New York, New York 9,348 followers
Advancing science with curative potential for both cardiovascular and APOE4 associated Alzheimer's disease areas.
About us
Based in New York City, Lexeo Therapeutics is a clinical-stage genetic medicines company dedicated to transforming healthcare by applying pioneering science to fundamentally change how disease is treated. Building on groundbreaking research from Weill Cornell Medicine and the University of California San Diego, Lexeo partners with preeminent institutions on the cutting edge of gene therapy research. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4 associated Alzheimer's disease programs, and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing and commercialization. For more information, please visit www.lexeotx.com.
- Website
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http://www.lexeotx.com
External link for Lexeo Therapeutics
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- New York, New York
- Type
- Privately Held
- Founded
- 2018
Locations
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Primary
345 Park Avenue South
6th Floor
New York, New York 10010, US
Employees at Lexeo Therapeutics
Updates
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Did you know arrhythmogenic cardiomyopathy, or ACM (also known as ARVC), is a heart disease where heart muscle is replaced by fibrotic tissue and fatty deposits? This can lead to heart dysfunction and abnormalities in cardiac rhythm. Half of the estimated 130,000 people living with ACM in the US have a genetic underlying cause. A mutation/pathogenic variant in the PKP2 gene is the most common genetic driver of ACM, affecting about 60,000 people, although mutations in other genes can cause ACM as well. To date, there are no approved therapies that address the underlying genetic cause of ACM. Lexeo's investigational gene therapy, LX2020, is currently being evaluated in a phase 1/2 clinical trial called HEROIC-PKP2 for PKP2-ACM. Learn more about LX2020, Lexeo’s gene therapy candidate for PKP2-ACM: https://lnkd.in/gNWDX9aQ
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Today, we are pleased to share our second quarter 2024 financial results and recent corporate updates. Visit our ‘News & Events’ page to learn more about our latest progress. https://lnkd.in/eBcSeAaq
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Friedreich ataxia (FA) is a genetic disease that is caused by deficiency in the frataxin protein. Symptoms typically begin in childhood and impact the nervous system (such as impaired muscle coordination, movement issues) and the heart. As the disease progresses, most patients develop heart conditions such as hypertrophic cardiomyopathy and arrhythmias. Although cardiac complications are the leading cause of death in almost 2/3 of patients with FA, there is currently no approved treatment for the heart problems associated with FA. At Lexeo, we are developing LX2006 to address this significant unmet need to address these critical cardiac manifestations: https://lnkd.in/exYWF9U7
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We're thrilled to introduce the bright minds joining us this summer! Our interns play an important role in providing us with fresh perspectives, innovative ideas, and passion for science, all of which are invaluable to our team. Let's give a warm welcome to these future leaders! #OneLexeo
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We are thrilled to share that Jenny Robertson, our Chief Business and Legal Officer, will be participating in a panel discussion at the 11th Annual Summit for Women Leaders in Life Science on Lessons from Women Trailblazers in Life Sciences Law. Join Jenny for an inspiring session designed to empower women at all career stages. She will share her valuable insights on shattering the glass ceiling, thriving at the executive level, and balancing professional and personal goals. To learn more about the conference and its speakers, visit: https://lnkd.in/e8KRXTZc #OneLexeo #WomenInLeadership
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During #FAAwarenessMonth, our CEO Nolan Townsend and Jen Farmer, CEO of the Friedreich's Ataxia Research Alliance (FARA), sat down with Karen Jagoda on the Empowered Patient Podcast. Together, they dove deep into Friedreich ataxia, its cardiac manifestations and clinical research that may provide hope for those living with FA. Listen to the full episode here: https://lnkd.in/eM_zHqs5
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We are proud to share positive interim data of LX2006 for the treatment of Friedreich ataxia (FA) cardiomyopathy. Across two clinical trials – the SUNRISE-FA Phase 1/2 trial sponsored by Lexeo and a Phase 1A Weill Cornell Medicine investigator-initiated trial – LX2006 was well tolerated with no treatment-related serious adverse events, and clinically meaningful improvements in cardiac biomarkers were observed with increasing improvement over time. Read more here: https://lnkd.in/e2QD2YKA
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Lexeo will present interim clinical data on LX2006, an AAVrh10.hFXN gene therapy candidate for the treatment of Friedreich ataxia (FA) cardiomyopathy, on Monday July 15. The presentation will include an overview of the natural history of FA cardiomyopathy and summary of clinically meaningful endpoints, interim data from Lexeo’s ongoing SUNRISE-FA Phase 1/2 clinical trial and the ongoing Weill Cornell Medicine investigator-initiated trial, as well as an overview of program next steps. https://lnkd.in/e77gXJDN
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Happy Independence Day! We wish everyone a safe, celebratory, and fun holiday to mark our nation’s independence. #OneLexeo
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