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. 2015 Oct;54(7):1045-54.
doi: 10.1007/s00394-014-0781-1. Epub 2014 Oct 24.

Intake of dietary folate and folic acid in Germany based on different scenarios for food fortification with folic acid

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Intake of dietary folate and folic acid in Germany based on different scenarios for food fortification with folic acid

Yvonne Martiniak et al. Eur J Nutr. 2015 Oct.

Abstract

Purpose: Besides the adverse health effects of a low folate intake, the risks of high intakes of folic acid have moved into the focus. The aim of this study was to investigate the potential range of folate and folic acid intake of the German population under consideration of different fortification scenarios.

Methods: Food consumption data of 13,926 participants of the German National Nutrition Survey II (NVS II), collected with two 24-h recalls, were used to calculate the nutrient intake. The nutrient data are based on the German Nutrient Database (BLS), information from a market survey and analyses of multivitamin juices. The scenarios were modelled without, as well as with low and high fortification levels of folic acid.

Results: The median intake of dietary folate equivalents ranged from 191 µg/d (men) and 168 µg/d (women) without fortification to 425 µg/d (men) and 334 µg/d (women) in the highest fortification scenario. Thus, 12.4-68.2% (men) and 5.9-56.1% (women) met the 300 µg/d recommended by the nutrition societies of Germany, Austria and Switzerland. In the highest fortification scenario, 1.9% (men) and 0.8% (women) exceeded the tolerable upper intake level (UL) of 1,000 µg/d folic acid given by the European Food Safety Authority. For supplement users, this proportion was 5.2 and 5.4%.

Conclusions: Only a high fortification of several foods leads to a marked increase of the proportion of population reaching the recommendation. Simultaneously, with a high fortification a higher proportion exceeds the UL, especially in combination with supplements.

Keywords: Dietary folate intake; Folic acid; Fortification; German National Nutrition Survey; Supplementation.

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Figures

Fig. 1
Fig. 1
Intake of dietary folate equivalents (DFE) in the German population (n = 13,926) by gender for different fortification scenarios (excluding supplements). Boxplots show median, upper and lower quartiles and minimum and maximum data values excluding extreme values and outliers

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References

    1. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 2000;71:1295S–1303S. - PubMed
    1. Wald NJ. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. 1991;338:131–137. doi: 10.1016/0140-6736(91)92605-2. - DOI - PubMed
    1. Czeizel AE. Nutritional supplementation and prevention of congenital abnormalities. Curr Opin Obstet Gynecol. 1995;7:88–94. doi: 10.1097/00001703-199504000-00003. - DOI - PubMed
    1. Blom HJ, Smulders Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis. 2011;34:75–81. doi: 10.1007/s10545-010-9177-4. - DOI - PMC - PubMed
    1. Duthie SJ. Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherit Metab Dis. 2011;34:101–109. doi: 10.1007/s10545-010-9128-0. - DOI - PubMed

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