File:Cancer metastasis and neural crest cell migration exhibit striking similarities.jpg
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| Description | Fig. 10. Cancer metastasis and neural crest cell migration exhibit striking similarities. (A) Pre-migratory NC cells and benign tumour cells show high levels of TGFβ/BMP, Wnt and FGF/Receptor Tyrosine Kinase (RTK) signaling activity. (B) These pathways induce the expression of transcription factors of the Snail, Twist, Sox, Fox and Ets families that trigger EMT. (C) Among the changes happening during EMT, the change of cell–cell adhesion properties allows NC cells and malignant tumour cells to separate from their original tissue. (D) In addition, NC cells and tumour cells express various proteinases of the MMP and ADAM families that further contribute to the modification of cell adhesion properties by promoting remodeling of the ECM and shedding of cell surface molecules including Cadherins. (E) NC cells and tumour cells migrate in a solitary or collective fashion. Both NC cells and cancer cells make use of pre-existing structures such as nerves and blood vessels for tumour cells or nerves and the basement membrane of epithelia (such as the ectoderm and the dermomyotome) for NC cells. In addition, they both respond to external signals controlling directional migration and homing into specific tissues and organs |
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https://www.sciencedirect.com/science/article/pii/S0012160611014692?via%3Dihub Neural crest delamination and migration: From epithelium-to-mesenchyme transition to collective cell migration, Developmental Biology, Volume 366, Issue 1, 2012, Pages 34-54, ISSN 0012-1606, https://doi.org/10.1016/j.ydbio.2011.12.041. (https://www.sciencedirect.com/science/article/pii/S0012160611014692) |
| Author | Eric Theveneau, Roberto Mayor, |
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| current | 07:59, 3 June 2024 | | 1,990 × 1,191 (428 KB) | Rasbak (talk | contribs) | {{Information |description=Fig. 10. Cancer metastasis and neural crest cell migration exhibit striking similarities. (A) Pre-migratory NC cells and benign tumour cells show high levels of TGFβ/BMP, Wnt and FGF/Receptor Tyrosine Kinase (RTK) signaling activity. (B) These pathways induce the expression of transcription factors of the Snail, Twist, Sox, Fox and Ets families that trigger EMT. (C) Among the changes happening during EMT, the change of cell–cell adhesion properties allows NC cells a... |
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