Jump to content

Fontolizumab: Difference between revisions

Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CAS_number').
OAbot (talk | contribs)
Bots
430,454 edits
m Open access bot: doi updated in citation with #oabot.
 
(15 intermediate revisions by 12 users not shown)
Line 1: Line 1:
{{Short description|Monoclonal antibody}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 444221666
| verifiedrevid =

<!--Monoclonal antibody data-->
<!--Monoclonal antibody data-->
| type = mab
| type = mab
| mab_type = mab
| mab_type = mab
| source = zu/o
| source = zu/o
| target = [[interferon gamma]]
| target = [[interferon gamma]]
⚫
<!--Clinical data-->

⚫
<!--Clinical data-->
| tradename =
| tradename =
| pregnancy_AU =
| pregnancy_AU =
Line 20: Line 20:
| legal_status =
| legal_status =
| routes_of_administration =
| routes_of_administration =
⚫
<!--Pharmacokinetic data-->

⚫
<!--Pharmacokinetic data-->
| bioavailability =
| bioavailability =
| protein_bound =
| protein_bound =
Line 27: Line 26:
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =
⚫
<!--Identifiers-->

⚫
<!--Identifiers-->
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = NA
| ChemSpiderID =
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number_Ref = {{cascite||??}}
| CAS_number = <!-- blanked - oldvalue: 326859-36-3 -->
| CAS_number = 326859-36-3
| ATC_prefix = none
| ATC_prefix = none
| ATC_suffix =
| ATC_suffix =
Line 42: Line 40:
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D04242
| KEGG = D04242
⚫
<!--Chemical data-->

⚫
<!--Chemical data-->
| chemical_formula =
| chemical_formula =
⚫
| molecular_weight = ca. 150

⚫
| molecular_weight = ca. 150 [[kDa]]
}}
}}
'''Fontolizumab''' (planned trade name '''HuZAF''') is a [[humanize]]d [[monoclonal antibody]]<ref>[http://www.ama-assn.org/ama1/pub/upload/mm/365/fontolizumab.doc Statement On A Nonproprietary Name Adopted By The Usan Council - Fontolizumab], ''American Medical Association''.</ref> and an [[immunosuppressive drug]] for the treatment of [[auto-immune disease]]s like [[Crohn's disease]].<ref>{{cite journal|pmid=19637334|year=2009|last1=Reinisch|first1=W|last2=De Villiers|first2=W|last3=Bene|first3=L|last4=Simon|first4=L|last5=Rácz|first5=I|last6=Katz|first6=S|last7=Altorjay|first7=I|last8=Feagan|first8=B|last9=Riff|first9=D|title=Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study|doi=10.1002/ibd.21038|journal=Inflammatory bowel diseases|pages=NA|volume=16|issue=2}}</ref> A phase II [[clinical trial]] investigating the use for [[rheumatoid arthritis]] was terminated because the first phase did not meet the [[clinical endpoint|endpoint]].<ref>{{ClinicalTrialsGov|NCT00281294|A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid Arthritis}}</ref>
'''Fontolizumab''' (planned trade name '''HuZAF''') is a [[ monoclonal antibody]]<ref>[http://www.ama-assn.org/ama1/pub/upload/mm/365/fontolizumab.doc Statement On A Nonproprietary Name Adopted By The Usan Council - Fontolizumab], ''American Medical Association''.</ref> and an [[immunosuppressive drug]] for the treatment of [[auto-immune disease]]s like [[Crohn's disease]].<ref>{{cite journal|=ReinischW VilliersWBeneLSimonLRáczIKatzSAltorjayIFeaganBRiff|=|title=Fontolizumab in moderate to severe Crohn's disease: phase 2, randomized, double-blind, placebo-controlled, multiple-dose study|doi=10.1002/ibd.21038|= |=}}</ref> A phase II [[clinical trial]] investigating the use for [[rheumatoid arthritis]] was terminated because the first phase did not meet the [[clinical endpoint|endpoint]].<ref>{{ClinicalTrialsGov|NCT00281294|A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid Arthritis}}</ref>


== References ==
== References ==
{{reflist}}
<references/>


{{Immunosuppressants}}
{{immunosuppressants}}
{{Monoclonals for immune system}}
{{Monoclonals for immune system}}
{{Cytokine receptor modulators}}


[[Category:Monoclonal antibodies]]
[[Category:Abandoned drugs]]


{{monoclonal-antibody-stub}}
{{monoclonal-antibody-stub}}
{{antineoplastic-drug-stub}}
{{antineoplastic-drug-stub}}

[[it:Fontolizumab]]
Retrieved from "https://en.wikipedia.org/wiki/Special:ComparePages"