C8 complex
Appearance
![](http://178.128.105.246/host-http-upload.wikimedia.org/wikipedia/commons/thumb/3/38/3OJY.png/220px-3OJY.png)
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
![](http://178.128.105.246/host-http-upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Formowanie_MAC.svg/400px-Formowanie_MAC.svg.png)
|
|
|
|
Structure
[edit]C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
[edit]- ^ PDB: 3OJY; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.
External links
[edit]- Complement+C8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)