Association between a novel human coronavirus and Kawasaki disease
- PMID: 15655771
- PMCID: PMC7199489
- DOI: 10.1086/428291
Association between a novel human coronavirus and Kawasaki disease
Abstract
Kawasaki disease is a systemic vasculitis of childhood; its etiology is unknown. We identified evidence of a novel human coronavirus, designated "New Haven coronavirus" (HCoV-NH), in respiratory secretions from a 6-month-old infant with classic Kawasaki disease. To further investigate the possible association between HCoV-NH infection and Kawasaki disease, we conducted a case-control study. Specimens of respiratory secretions from 8 (72.7%) of 11 children with Kawasaki disease and from 1 (4.5%) of 22 control subjects (children without Kawasaki disease matched by age and the time the specimens were obtained) tested positive for HCoV-NH by reverse-transcriptase polymerase chain reaction (Mantel-Haenszel matched odds ratio, 16.0 [95% confidence interval, 3.4-74.4]; P=.0015). These data suggest that HCoV-NH infection is associated with Kawasaki disease.
Comment in
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Coronaviruses in the limelight.J Infect Dis. 2005 Feb 15;191(4):489-91. doi: 10.1086/428510. Epub 2005 Jan 14. J Infect Dis. 2005. PMID: 15655769 Free PMC article. No abstract available.
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Lack of association between New Haven coronavirus and Kawasaki disease.J Infect Dis. 2005 Jul 15;192(2):351-2; author reply 353. doi: 10.1086/430797. J Infect Dis. 2005. PMID: 15962233 Free PMC article. No abstract available.
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Kawasaki disease and human coronavirus.J Infect Dis. 2005 Jul 15;192(2):352-3; author reply 353. doi: 10.1086/431609. J Infect Dis. 2005. PMID: 15962234 Free PMC article. No abstract available.
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