Nanotherapeutics to overcome conventional cancer chemotherapy limitations
- PMID: 21501554
- DOI: 10.18433/j30c7d
Nanotherapeutics to overcome conventional cancer chemotherapy limitations
Abstract
Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy.
Similar articles
-
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.Eur J Pharm Biopharm. 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. Epub 2015 Mar 23. Eur J Pharm Biopharm. 2015. PMID: 25813885 Review.
-
Therapeutic nanoparticles for drug delivery in cancer.Clin Cancer Res. 2008 Mar 1;14(5):1310-6. doi: 10.1158/1078-0432.CCR-07-1441. Clin Cancer Res. 2008. PMID: 18316549 Review.
-
Promising effects of nanomedicine in cancer drug delivery.J Drug Target. 2018 Apr;26(4):319-324. doi: 10.1080/1061186X.2017.1377207. Epub 2017 Sep 18. J Drug Target. 2018. PMID: 28875739 Review.
-
The achievement of ligand-functionalized organic/polymeric nanoparticles for treating multidrug resistant cancer.Expert Opin Drug Deliv. 2017 Aug;14(8):937-957. doi: 10.1080/17425247.2017.1247804. Epub 2016 Oct 27. Expert Opin Drug Deliv. 2017. PMID: 27759437 Review.
-
Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors.Colloids Surf B Biointerfaces. 2019 Jan 1;173:581-590. doi: 10.1016/j.colsurfb.2018.10.022. Epub 2018 Oct 10. Colloids Surf B Biointerfaces. 2019. PMID: 30352379 Review.
Cited by
-
Nanomaterials in Immunology: Bridging Innovative Approaches in Immune Modulation, Diagnostics, and Therapy.J Funct Biomater. 2024 Aug 14;15(8):225. doi: 10.3390/jfb15080225. J Funct Biomater. 2024. PMID: 39194663 Free PMC article. Review.
-
Development of modular polymeric nanoparticles for drug delivery using amine reactive chemistry.J Pharm Pharm Sci. 2024 Aug 6;27:13148. doi: 10.3389/jpps.2024.13148. eCollection 2024. J Pharm Pharm Sci. 2024. PMID: 39165831 Free PMC article.
-
Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery.RSC Adv. 2024 Aug 12;14(35):25149-25173. doi: 10.1039/d4ra03911d. eCollection 2024 Aug 12. RSC Adv. 2024. PMID: 39139249 Free PMC article. Review.
-
Synthesis of N-Alkyl-3-[2-oxoquinolin-1(2H)-yl]propanoic Acid Derivatives and Related Compounds: Cytotoxicity and EGFR Inhibition of Some Propanamide Derivatives.ACS Omega. 2024 Jul 17;9(30):32789-32798. doi: 10.1021/acsomega.4c03114. eCollection 2024 Jul 30. ACS Omega. 2024. PMID: 39100360 Free PMC article.
-
Core-Tunable Dendritic Polymer: A Folate-Guided Theranostic Nanoplatform for Drug Delivery Applications.ACS Omega. 2024 Jul 6;9(28):30544-30558. doi: 10.1021/acsomega.4c02258. eCollection 2024 Jul 16. ACS Omega. 2024. PMID: 39035936 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources