Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;60(2):601-604.

Correlations between infection patterns and eye damage in reactive arthritis

Simona Bănicioiu-Covei  1 , Ananu Florentin Vreju, Paulina Lucia Ciurea
Affiliations
  • PMID: 31658334
Free article

Correlations between infection patterns and eye damage in reactive arthritis

Simona Bănicioiu-Covei et al. Rom J Morphol Embryol. 2019.
Free article

Abstract

The purpose of the study was to correlate the infectious patterns (urogenital, enteral) with ocular manifestations, such as conjunctivitis or acute anterior uveitis in reactive arthritis (ReA). The transversal, observational study was conducted in the Clinic of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, during the period 2012-2015, and included 112 patients. They were divided into three groups, as follows: Group I (52 ReA cases), Group II (30 other spondyloarthritis cases), Group III (40 osteoarthritis cases). Ophthalmologic screening was performed, together with the detection of human leukocyte antigen B27 (HLA-B27) and the infectious trigger. Within Group I, 42 (80.76%) patients presented genitourinary infections (78.57% Chlamydia trachomatis, 21.43% Ureaplasma urealyticum), 10 (19.23%) patients presented enteral infections (Yersinia enterocolitica and Salmonella). Compared with the other two groups, the patients from the first group were documented with more conjunctivitis episodes. Although anterior uveitis is more common in ankylosing spondylitis (AS), in the present study more cases were identified in Group I (11.9%) than in Group II (6.67%) and no case were recorded in Group III. Most of patients from Group I were HLA-B27 positive. The etiologic profile of ocular manifestations in ReA is dominated by genitourinary infections - C. trachomatis and U. urealyticum, respectively. Cases of recurring uveitis are associated with elevated levels of anti-immunoglobulin A (IgA).

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Recent Developments in HLA B27 Anterior Uveitis.
    Wakefield D, Clarke D, McCluskey P. Wakefield D, et al. Front Immunol. 2021 Jan 5;11:608134. doi: 10.3389/fimmu.2020.608134. eCollection 2020. Front Immunol. 2021. PMID: 33469457 Free PMC article. Review.