28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.[5][6]

MRPS35
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS35, MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDsOMIM: 611995; MGI: 2385255; HomoloGene: 11048; GeneCards: MRPS35; OMA:MRPS35 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021821
NM_001190864

NM_145573

RefSeq (protein)

NP_001177793
NP_068593

NP_663548

Location (UCSC)Chr 12: 27.71 – 27.76 MbChr 6: 146.94 – 146.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000061794Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040112Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. ^ a b "Entrez Gene: MRPS35 mitochondrial ribosomal protein S35".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P82673 (28S ribosomal protein S35, mitochondrial) at the PDBe-KB.