Paralemmin is a protein that in humans is encoded by the PALM gene.[5][6][7]

PALM
Identifiers
AliasesPALM, paralemmin, PALM1
External IDsOMIM: 608134; MGI: 1261814; HomoloGene: 1937; GeneCards: PALM; OMA:PALM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040134
NM_002579

NM_001161747
NM_023128

RefSeq (protein)

NP_001035224
NP_002570

NP_001155219
NP_075617

Location (UCSC)Chr 19: 0.71 – 0.75 MbChr 10: 79.63 – 79.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the paralemmin protein family. Other members of this family include CAP-23, GAP-43, MARCKS, and MacMARCKS. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types.[5][6] Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099864Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035863Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Burwinkel B, Miglierini G, Jenne DE, Gilbert DJ, Copeland NG, Jenkins NA, Ring HZ, Francke U, Kilimann MW (Aug 1998). "Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice". Genomics. 49 (3): 462–6. doi:10.1006/geno.1998.5276. PMID 9615234.
  6. ^ a b Kutzleb C, Sanders G, Yamamoto R, Wang X, Lichte B, Petrasch-Parwez E, Kilimann MW (Dec 1998). "Paralemmin, a Prenyl-Palmitoyl–anchored Phosphoprotein Abundant in Neurons and Implicated in Plasma Membrane Dynamics and Cell Process Formation". J Cell Biol. 143 (3): 795–813. doi:10.1083/jcb.143.3.795. PMC 2148134. PMID 9813098.
  7. ^ a b "Entrez Gene: PALM paralemmin".

Further reading

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