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KYAT1

S Wikipedije, slobodne enciklopedije
KYAT1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1W7L, 1W7M, 1W7N, 3FVS, 3FVU, 3FVX, 4WLH, 4WLJ, 4WP0

Identifikatori
AliasiKYAT1
Vanjski ID-jeviOMIM: 600547 MGI: 1917516 HomoloGene: 37872 GeneCards: KYAT1
EC broj4.4.1.13
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[1]
Hromosom 2 (miš)
Genomska lokacija za KYAT1
Genomska lokacija za KYAT1
Bend2|2 BPočetak30,075,136 bp[1]
Kraj30,095,859 bp[1]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
kynurenine-oxoglutarate transaminase activity
protein homodimerization activity
L-glutamine:pyruvate aminotransferase activity
transaminase activity
glutamine-phenylpyruvate transaminase activity
GO:0001948, GO:0016582 vezivanje za proteine
catalytic activity
lyase activity
L-phenylalanine:pyruvate aminotransferase activity
pyridoxal phosphate binding
L-glutamine aminotransferase activity
cysteine-S-conjugate beta-lyase activity
Ćelijska komponenta nukleoplazma
citoplazma
citosol
mitohondrija
Biološki proces L-phenylalanine catabolic process
cellular amino acid biosynthetic process
Biosinteza
L-kynurenine catabolic process
tryptophan catabolic process
cellular modified amino acid metabolic process
kynurenine metabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001122671
NM_001122672
NM_001287390
NM_004059

NM_172404
NM_001356474
NM_001356475

RefSeq (bjelančevina)
NP_001116143
NP_001116144
NP_001274319
NP_004050
NP_001339917

NP_001339918
NP_001339919
NP_001339920
NP_001339921
NP_001339922
NP_001339923
NP_001339924
NP_001339925
NP_001339926
NP_001339927
NP_001339928

NP_765992
NP_001343403
NP_001343404

Lokacija (UCSC)n/aChr 2: 30.08 – 30.1 Mb
PubMed pretraga[2][3]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Kinureninska oksoglutarat-transaminaza 1 je enzim koji je kod ljudi kodiran genom CCBL1.[4][5] To je jedna od kinurenin-oksoglutarat transaminaza.

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 422 aminokiseline, а molekulska težina 47.875 Da.[6]

1020304050
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAF
QHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGG
YGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQ
NGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVA
SLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFS
ATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRK
MPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFC
FVKDEATLQAMDEKLRKWKVEL

Funkcija

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Ovaj gen kodira citosolni enzim koji je odgovoran za metabolizam cisteinskih konjugata određenih halogeniranih alkena i alkana. Taj metabolizam dovodi do stvaranja reaktivnih metabolita koji mogu dovesti do nefrotoksičnosti i neurotoksičnosti.[5]

Reference

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039648 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Perry S, Harries H, Scholfield C, Lock T, King L, Gibson G, Goldfarb P (Apr 1995). "Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase". FEBS Lett. 360 (3): 277–80. doi:10.1016/0014-5793(95)00123-Q. PMID 7883047. S2CID 83606450.
  5. ^ a b "Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)".
  6. ^ "UniProt, Q16773". Pristupljeno 9. 9. 2021.

Dopunska literatura

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Vanjski linkovi

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