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PLAGL1

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PLAGL1
Identifikatori
AliasiPLAGL1
Vanjski ID-jeviOMIM: 603044 MGI: 1100874 HomoloGene: 31401 GeneCards: PLAGL1
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za PLAGL1
Genomska lokacija za PLAGL1
Bend6q24.2Početak143,940,300 bp[1]
Kraj144,064,599 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za PLAGL1
Genomska lokacija za PLAGL1
Bend10 A2|10 4.72 cMPočetak13,060,504 bp[2]
Kraj13,131,694 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
nucleic acid binding
vezivanje iona metala
vezivanje sa DNK
RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta Golđijev aparat
intracellular membrane-bounded organelle
jedro
nukleoplazma
nuclear body
Biološki proces Ćelijska diferencijacija
GO:0009373 regulation of transcription, DNA-templated
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
transcription, DNA-templated
GO:0097285 apoptoza
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
transcription by RNA polymerase II
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_006718
NM_001080951
NM_001080952
NM_001080953
NM_001080954

NM_001080955
NM_001080956
NM_001289037
NM_001289038
NM_001289039
NM_001289040
NM_001289041
NM_001289042
NM_001289043
NM_001289044
NM_001289045
NM_001289046
NM_001289047
NM_001289048
NM_001289049
NM_002656
NM_001317156
NM_001317157
NM_001317158
NM_001317159
NM_001317160
NM_001317161
NM_001317162

NM_009538

RefSeq (bjelančevina)
NP_001074420
NP_001074421
NP_001074422
NP_001074423
NP_001074424

NP_001074425
NP_001275966
NP_001275967
NP_001275968
NP_001275969
NP_001275970
NP_001275971
NP_001275972
NP_001275973
NP_001275974
NP_001275975
NP_001275976
NP_001275977
NP_001275978
NP_001304085
NP_001304086
NP_001304087
NP_001304088
NP_001304089
NP_001304090
NP_001304091
NP_006709

n/a

Lokacija (UCSC)Chr 6: 143.94 – 144.06 MbChr 10: 13.06 – 13.13 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein cinkovog prsta PLAGL1 jest protein koji je kod ljudi kodiran genom PLAGL1.[5][6][7]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 463 aminokiseline, а molekulska težina 50.819 Da.[8]

1020304050
MATFPCQLCGKTFLTLEKFTIHNYSHSRERPYKCVQPDCGKAFVSRYKLM
RHMATHSPQKSHQCAHCEKTFNRKDHLKNHLQTHDPNKMAFGCEECGKKY
NTMLGYKRHLALHAASSGDLTCGVCALELGSTEVLLDHLKAHAEEKPPSG
TKEKKHQCDHCERCFYTRKDVRRHLVVHTGCKDFLCQFCAQRFGRKDHLT
RHTKKTHSQELMKESLQTGDLLSTFHTISPSFQLKAAALPPFPLGASAQN
GLASSLPAEVHSLTLSPPEQAAQPMQPLPESLASLHPSVSPGSPPPPLPN
HKYNTTSTSYSPLASLPLKADTKGFCNISLFEDLPLQEPQSPQKLNPGFD
LAKGNAGKVNLPKELPADAVNLTIPASLDLSPLLGFWQLPPPATQNTFGN
STLALGPGESLPHRLSCLGQQQQEPPLAMGTVSLGQLPLPPIPHVFSAGT
GSAILPHFHHAFR

Funkcija

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Ovaj gen kodira C2H2 protein cinkovog prsta s transaktivacijom i vezanjem za DNK. Pokazalo se da pokazuje antiproliferativne aktivnosti i kandidat je za supresora tumora. Za ovaj gen pronađene su mnoge varijante transkripta koje kodiraju dvije različite izoforme.[7]

Interakcije

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Pokazano je da PLAGL1 stupa u interakciju sa P53.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118495 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019817 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
  6. ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. Bibcode:1998PNAS...95.8835V. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
  7. ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
  8. ^ "UniProt, Q9UM63" (jezik: engleski). Pristupljeno 10. 10. 2021.
  9. ^ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.

Further reading

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