S Wikipedije, slobodne enciklopedije
Protein 1 sa vezivanjem WW domena jest protein koji je kod ljudi kodiran genom WBP1 sa hromosoma 2 .[ 5] [ 6]
Dužina polipeptidnog lanca je 269 aminokiselina , a molekulska težina Da . 29 140[ 7]
10 20 30 40 50
MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC
TYYYELWWFW LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG
ACHGAGPFPT GSLLDLRFLS TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT
ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ SAPPHQEGEP GAGVTPASTP
PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL EDYSPCALPP
ESVPQIFPMG LSSSEGDIP
Globulasti WW domen sastoji se od 38 do 40 polukonzerviranih aminokiselina koje dijele proteini različitih funkcija uključujući strukturne, regulatorne i signalne proteine Domen je uključen u posredovanje interakcija protein-protein , putem međusobnog vezivanjs proteina. poliprolinskog liganda .
Ovaj gen kodira protein koji se vezuje za WW domen, vezan za WW domen proteina povezanog sa kinazom Yes, pomoću konzerviranopgg regiona: motiva XPPXY. Funkcija ovog proteina nije utvrđena.[ 6]
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins" . Oncogene . 23 (29): 5049–55. doi :10.1038/sj.onc.1207680 . PMC 4143251 . PMID 15064722 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4" . Biochem. J . 351 Pt 3 (3): 557–65. doi :10.1042/0264-6021:3510557 . PMC 1221394 . PMID 11042109 .
Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands" . J. Biol. Chem . 272 (27): 17070–7. doi :10.1074/jbc.272.27.17070 . PMID 9202023 .
Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets" . J. Biol. Chem . 272 (23): 14611–6. doi :10.1074/jbc.272.23.14611 . PMID 9169421 .