Idi na sadržaj

ZNF536

S Wikipedije, slobodne enciklopedije
ZNF536
Identifikatori
AliasiZNF536
Vanjski ID-jeviOMIM: 618037 MGI: 1926102 HomoloGene: 8813 GeneCards: ZNF536
Lokacija gena (čovjek)
Hromosom 19 (čovjek)
Hrom.Hromosom 19 (čovjek)[1]
Hromosom 19 (čovjek)
Genomska lokacija za ZNF536
Genomska lokacija za ZNF536
Bend19q12Početak30,228,290 bp[1]
Kraj30,713,538 bp[1]
Lokacija gena (miš)
Hromosom 7 (miš)
Hrom.Hromosom 7 (miš)[2]
Hromosom 7 (miš)
Genomska lokacija za ZNF536
Genomska lokacija za ZNF536
Bend7|7 B2-B3Početak37,318,024 bp[2]
Kraj37,773,641 bp[2]
Ontologija gena
Molekularna funkcija GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
vezivanje sa DNK
GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
retinoic acid-responsive element binding
vezivanje iona metala
nucleic acid binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta jedro
Biološki proces negative regulation of retinoic acid receptor signaling pathway
multicellular organism development
GO:0009373 regulation of transcription, DNA-templated
GO:1901227 negative regulation of transcription by RNA polymerase II
negative regulation of neuron differentiation
GO:0072468 Transdukcija signala
transcription, DNA-templated
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_014717
NM_001352260
NM_001376110
NM_001376111

NM_172385

RefSeq (bjelančevina)

NP_055532
NP_001339189
NP_001363039
NP_001363040

NP_759017
NP_001391020
NP_001391022
NP_001391023
NP_001391024

NP_001391025
NP_001391026
NP_001391028
NP_001391029

Lokacija (UCSC)Chr 19: 30.23 – 30.71 MbChr 7: 37.32 – 37.77 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 536 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF536.[5]

Aminokiselinska sekvenca
Simboli
1020304050
MEEASLCLGVSSAEPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPEL
HPRPNPEEKPPASLEEKAHVPMSGQPMGSQMALLANQLGREVDTSLNGRV
DLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMR
THTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLH
ELEERAILRDKQLKGSLLQPRPDLKPPPHAQQAPLAACTLALQANHSVPD
VAHPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPY
KCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVC
GQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLS
VKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMTPDKAGLSEPS
QLYGKGELPMKEKEALGKLLSPISSMAHGVPEGDKHSLLGCLNLVPPLKS
SCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHPLQRNHED
TLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGSQRDLPSKLDP
LESSRDFLSHGLNQTLEYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHS
RVHKRDRKGEEDGLHVGLDERRGSGSDQESQSVSRSTTPGSSNVTEESGV
GGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAM
KDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLER
HHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRGAFKGLPGIDF
RGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEI
GRAYQSIVSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVH
GVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAW
HGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASK
MALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHV
DPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIP
ETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKD
SSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPK
PERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCGK

Interakcije

[uredi | uredi izvor]

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[5]

Reference

[uredi | uredi izvor]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198597 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043456 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Zinc finger protein 536".

Dopunska literatura

[uredi | uredi izvor]

Vanjski linkovi

[uredi | uredi izvor]