IL4 |
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Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Rhestr o ddynodwyr PDB |
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1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX |
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Dynodwyr |
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Cyfenwau | IL4, Interleukin 4, IL-4 |
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Dynodwyr allanol | HomoloGene: 491 GeneCards: IL4 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • interleukin-4 receptor binding • GO:0001948, GO:0016582 protein binding • growth factor activity • GO:0005145 cytokine receptor binding • cytokine activity
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Cydrannau o'r gell | • extracellular region • extracellular space
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Prosesau biolegol | • positive regulation of T cell differentiation • dendritic cell differentiation • negative regulation of endothelial cell apoptotic process • negative regulation of complement-dependent cytotoxicity • regulation of phosphorylation • negative regulation of apoptotic process • myeloid dendritic cell differentiation • type 2 immune response • B cell activation • positive regulation of interleukin-13 production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of epithelial cell migration • regulation of signaling receptor activity • cholesterol metabolic process • positive regulation of B cell proliferation • positive regulation of T cell proliferation • T cell activation • positive regulation of MHC class II biosynthetic process • negative regulation of osteoclast differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of isotype switching to IgE isotypes • positive regulation of isotype switching to IgG isotypes • regulation of immune response • cytokine-mediated signaling pathway • GO:1901313 positive regulation of gene expression • positive regulation of macroautophagy • positive regulation of tyrosine phosphorylation of STAT protein • activation of Janus kinase activity • positive regulation of receptor-mediated endocytosis • positive regulation of cold-induced thermogenesis • negative regulation of neuroinflammatory response • positive regulation of amyloid-beta clearance • neuroinflammatory response • positive regulation of cellular respiration • positive regulation of ATP biosynthetic process
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn IL4 yw IL4 a elwir hefyd yn Interleukin 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL4.
- BSF1
- IL-4
- BCGF1
- BSF-1
- BCGF-1
- "IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. ". Cancer Res. 2017. PMID 28400477.
- "Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women. ". Genet Mol Res. 2017. PMID 28387873.
- "Genotyping of IL-4-590 (C>T) Gene in Iraqi Asthma Patients. ". Dis Markers. 2017. PMID 28386156.
- "Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt. ". J Infect Dev Ctries. 2017. PMID 28368861.
- "Interleukin 4 -590C/T (rs2243250) Polymorphism Is Associated With Increased Risk of Atopic Dermatitis: Meta-Analysis of Case-Control Studies.". Dermatitis. 2017. PMID 28169853.