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HIST3H2BB

From Wikipedia, the free encyclopedia
H2BU1
Identifiers
AliasesH2BU1, H2Bb, histone cluster 3, H2bb, histone cluster 3 H2B family member b, H2B.U histone 1, HIST3H2BB
External IDsOMIM: 615046; MGI: 1922442; HomoloGene: 75941; GeneCards: H2BU1; OMA:H2BU1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175055

NM_001393523

RefSeq (protein)

NP_778225

n/a

Location (UCSC)Chr 1: 228.46 – 228.46 MbChr 11: 58.84 – 58.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.[5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 base pairs (bp) of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.[6]

References

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  1. ^ a b c ENSG00000285449 GRCh38: Ensembl release 89: ENSG00000196890, ENSG00000285449Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080712Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. ^ a b "Entrez Gene: HIST3H2BB histone cluster 3, H2bb".

Further reading

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