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SPINT1

From Wikipedia, the free encyclopedia

SPINT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPINT1, HAI, HAI1, MANSC2, serine peptidase inhibitor, Kunitz type 1
External IDsOMIM: 605123; MGI: 1338033; HomoloGene: 9653; GeneCards: SPINT1; OMA:SPINT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016907

RefSeq (protein)

NP_001027539
NP_003701
NP_857593

NP_058603

Location (UCSC)Chr 15: 40.84 – 40.86 MbChr 2: 119.07 – 119.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kunitz-type protease inhibitor 1 is an enzyme that in humans is encoded by the SPINT1 gene.[5]

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166145Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027315Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SPINT1 serine peptidase inhibitor, Kunitz type 1".

Further reading

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