ADD2
A beta-adducina é uma proteína que em humanos é codificada pelo gene ADD2.[2][3]
As adducinas são uma família de proteínas do citoesqueleto codificadas por três genes (alfa, beta, gama). A adducina é uma proteína heterodimérica que consiste em subunidades relacionadas, produzidas a partir de genes distintos, mas que compartilham uma estrutura semelhante. A alfa e a beta-adducina incluem uma região N-terminal resistente a protease e uma região C-terminal hidrofílica sensível a protease. A beta-adducina é expressa em altos níveis no cérebro e nos tecidos hematopoiéticos. A aducina se liga com alta afinidade ao Ca2+/calmodulina e é um substrato para as proteínas cinases A e C. A emenda[4] alternativa resulta em múltiplas variantes que codificam isoformas[5] distintas; no entanto, nem todas as variantes foram totalmente descritas.[6]
Interações
[editar | editar código-fonte]Foi mostrado que o ADD2 interage com o FYN.[7]
Referências
[editar | editar código-fonte]- ↑ «Human PubMed Reference:»
- ↑ Joshi R, Gilligan DM, Otto E, McLaughlin T, Bennett V (novembro de 1991). «Primary structure and domain organization of human alpha and beta adducin». J Cell Biol. 115 (3): 665–75. PMC 2289184. PMID 1840603. doi:10.1083/jcb.115.3.665
- ↑ «Entrez Gene: ADD2 adducin 2 (beta)»
- ↑ Hirata R, Ohsumk Y, Nakano A, Kawasaki H, Suzuki K, Anraku Y (abril de 1990). «Molecular structure of a gene, VMA1, encoding the catalytic subunit of H(+)-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae». J. Biol. Chem. 265 (12): 6726–33. PMID 2139027
- ↑ Schlüter H, Apweiler R, Holzhütter HG, Jungblut PR (setembro de 2009). «Finding one's way in proteomics: a protein species nomenclature». Chemistry Central Journal. 3. 11 páginas. PMC 2758878. PMID 19740416. doi:10.1186/1752-153X-3-11
- ↑ «Entrez Gene: ADD1 adducin 1 (alpha)»
- ↑ Shima T, Okumura N, Takao T, Satomi Y, Yagi T, Okada M, Nagai K (novembro de 2001). «Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin». J. Biol. Chem. 276 (45): 42233–40. PMID 11526103. doi:10.1074/jbc.M102699200
Leitura adicional
[editar | editar código-fonte]- Gilligan DM, Lieman J, Bennett V (1996). «Assignment of the human beta-adducin gene (ADD2) to 2p13-p14 by in situ hybridization». Genomics. 28 (3): 610–2. PMID 7490111. doi:10.1006/geno.1995.1205
- Hughes CA, Bennett V (1995). «Adducin: a physical model with implications for function in assembly of spectrin-actin complexes». J. Biol. Chem. 270 (32): 18990–6. PMID 7642559. doi:10.1074/jbc.270.32.18990
- Miyazaki M, Kaibuchi K, Shirataki H, et al. (1995). «Rabphilin-3A binds to a M(r) 115,000 polypeptide in a phosphatidylserine- and Ca(2+)-dependent manner». Brain Res. Mol. Brain Res. 28 (1): 29–36. PMID 7707875. doi:10.1016/0169-328X(94)00180-M
- Miyazaki M, Shirataki H, Kohno H, et al. (1995). «Identification as beta-adducin of a protein interacting with rabphilin-3A in the presence of Ca2+ and phosphatidylserine». Biochem. Biophys. Res. Commun. 205 (1): 460–6. PMID 7999065. doi:10.1006/bbrc.1994.2688
- White RA, Angeloni SV, Pasztor LM (1996). «Chromosomal localization of the beta-adducin gene to mouse chromosome 6 and human chromosome 2». Mamm. Genome. 6 (10): 741–3. PMID 8563174. doi:10.1007/BF00354298
- Tisminetzky S, Devescovi G, Tripodi G, et al. (1996). «Genomic organisation and chromosomal localisation of the gene encoding human beta adducin». Gene. 167 (1–2): 313–6. PMID 8566798. doi:10.1016/0378-1119(95)00591-9
- Matsuoka Y, Hughes CA, Bennett V (1996). «Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C». J. Biol. Chem. 271 (41): 25157–66. PMID 8810272. doi:10.1074/jbc.271.41.25157
- Gilligan DM, Lozovatsky L, Silberfein A (1997). «Organization of the human beta-adducin gene (ADD2)». Genomics. 43 (2): 141–8. PMID 9244430. doi:10.1006/geno.1997.4802
- Matsuoka Y, Li X, Bennett V (1998). «Adducin Is an In Vivo Substrate for Protein Kinase C: Phosphorylation in the MARCKS-related Domain Inhibits Activity in Promoting Spectrin–Actin Complexes and Occurs in Many Cells, Including Dendritic Spines of Neurons». J. Cell Biol. 142 (2): 485–97. PMC 2133059. PMID 9679146. doi:10.1083/jcb.142.2.485
- Gilligan DM, Lozovatsky L, Gwynn B, et al. (1999). «Targeted disruption of the β adducin gene (Add2) causes red blood cell spherocytosis in mice». Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10717–22. PMC 17949. PMID 10485892. doi:10.1073/pnas.96.19.10717
- Shima T, Okumura N, Takao T, et al. (2001). «Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin». J. Biol. Chem. 276 (45): 42233–40. PMID 11526103. doi:10.1074/jbc.M102699200
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Citterio L, Tizzoni L, Catalano M, et al. (2003). «Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants». Biochem. Biophys. Res. Commun. 309 (2): 359–67. PMID 12951058. doi:10.1016/j.bbrc.2003.08.011
- Tikhonoff V, Kuznetsova T, Stolarz K, et al. (2004). «beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations». Am. J. Hypertens. 16 (10): 840–6. PMID 14553963. doi:10.1016/S0895-7061(03)00975-0
- Brandenberger R, Wei H, Zhang S, et al. (2005). «Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation». Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971
- Ballif BA, Villén J, Beausoleil SA, et al. (2005). «Phosphoproteomic analysis of the developing mouse brain». Mol. Cell. Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Efendiev R, Krmar RT, Ogimoto G, et al. (2005). «Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium». Circ. Res. 95 (11): 1100–8. PMID 15528469. doi:10.1161/01.RES.0000149570.20845.89
- Lanzani C, Citterio L, Jankaricova M, et al. (2005). «Role of the adducin family genes in human essential hypertension». J. Hypertens. 23 (3): 543–9. PMID 15716695. doi:10.1097/01.hjh.0000160210.48479.78