Origem: Wikipédia, a enciclopédia livre.
O fator de pré-processamento de mRNA 17 é uma proteína que em humanos é codificada pelo gene CDC40.[2][3][4]
A junção pré-mRNA ocorre em duas etapas de transesterificação sequenciais. A proteína codificada por este gene é considerada essencial para a etapa catalítica II no processo de emenda do pré-mRNA. É encontrado no spliceossomo e contém sete repetições WD, que funcionam nas interações proteína-proteína.[5][4]
Referências
- Wong WT, Schumacher C, Salcini AE, et al. (1995). «A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution». Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. PMC 40835
. PMID 7568168. doi:10.1073/pnas.92.21.9530
- Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides». Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
- Bonaldo MF, Lennon G, Soares MB (1997). «Normalization and subtraction: two approaches to facilitate gene discovery». Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791
- Salcini AE, Confalonieri S, Doria M, et al. (1997). «Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module». Genes Dev. 11 (17): 2239–49. PMC 275390
. PMID 9303539. doi:10.1101/gad.11.17.2239
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
- Zhou Z, Reed R (1998). «Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing». EMBO J. 17 (7): 2095–106. PMC 1170554
. PMID 9524131. doi:10.1093/emboj/17.7.2095
- Ben-Yehuda S, Dix I, Russell CS, et al. (2001). «Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae». Genetics. 156 (4): 1503–17. PMC 1461362
. PMID 11102353
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). «Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis». RNA. 8 (4): 426–39. PMC 1370266
. PMID 11991638. doi:10.1017/S1355838202021088
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). «High-throughput mapping of a dynamic signaling network in mammalian cells». Science. 307 (5715): 1621–5. PMID 15761153. doi:10.1126/science.1105776
- Olsen JV, Blagoev B, Gnad F, et al. (2006). «Global, in vivo, and site-specific phosphorylation dynamics in signaling networks». Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026