Origem: Wikipédia, a enciclopédia livre.
Substrato receptor 3 do fator de crescimento de fibroblastos é uma proteína que em humanos é codificada pelo gene FRS3.[2][3][4]
A proteína codificada por esse gene é um substrato para o receptor do fator de crescimento de fibroblastos. É encontrado na membrana plasmática periférica e funciona na ligação da estimulação do receptor FGF aos ativadores de Ras.[4]
Referências
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- Gotoh N, Laks S, Nakashima M, et al. (2004). «FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.». FEBS Lett. 564 (1-2): 14–8. PMID 15094036. doi:10.1016/S0014-5793(04)00287-X
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- Huang L, Gotoh N, Zhang S, et al. (2004). «SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.». Biochem. Biophys. Res. Commun. 324 (3): 1011–7. PMID 15485655. doi:10.1016/j.bbrc.2004.09.152
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- Harada A, Katoh H, Negishi M (2005). «Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.». J. Biol. Chem. 280 (18): 18418–24. PMID 15738000. doi:10.1074/jbc.M411356200
- Huang L, Watanabe M, Chikamori M, et al. (2006). «Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.». Oncogene. 25 (49): 6457–66. PMID 16702953. doi:10.1038/sj.onc.1209656