Пређи на садржај

Perindopril

С Википедије, слободне енциклопедије
Perindopril
IUPAC ime
(2S,3aS,7aS)-1-[(2S)-2- {[(2S)-1-etoksi-1-oksopentan-2-il]amino}propanoil]-oktahidro-1H-indol-2-karboksilna kiselina
Klinički podaci
Prodajno imeCoversyl, Coversum, Preterax, Aceon
Drugs.comMonografija
MedlinePlusa602017
Kategorija trudnoće
  • US: D (Evidencija rizika)
Način primeneOralno
Pravni status
Pravni status
Farmakokinetički podaci
Bioraspoloživost24%
Vezivanje proteina20%
MetabolizamRenal
Poluvreme eliminacije1—17 sati za perindoprilat (aktivni metabolit)
Identifikatori
CAS broj82834-16-0 ДаY
ATC kodC09AA04 (WHO)
C09BA04 (sa diureticima)
C09BB04 (sa amlodipinom)
PubChemCID 107807
DrugBankDB00790 ДаY
ChemSpider96956 ДаY
UNII1964X464OJ ДаY
KEGGD03753 ДаY
ChEBICHEBI:8024 ДаY
ChEMBLCHEMBL1581 ДаY
Hemijski podaci
FormulaC19H32N2O5
Molarna masa368,468 g/mol
  • O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@H]12)C)CCC
  • InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1 ДаY
  • Key:IPVQLZZIHOAWMC-QXKUPLGCSA-N ДаY

Perindopril je dugotrajni ACE inhibitor. On se koristi za tretman visokog krvnog pritiska, zatajenja srca i koronarne arterijske bolesti[1] u obliku perindopril arginina (Coversyl, Coversum) ili perindopril erbumina (Aceon). Ova dva preparata su terapeutski ekvivalentna.[2]

  1. ^ Royal Australian College of General Practitioners. „Consumer Medicine Information, GenRx Perindopril” (PDF). Clinical Resources, Medicine information for health professionals. Архивирано из оригинала (PDF) 01. 09. 2007. г. 
  2. ^ Australian Government Department of Health and Ageing (2008). „PBS For Health Professionals”. Pharmaceutical Benefits Scheme. Архивирано из оригинала 30. 10. 2008. г. Приступљено 4. 9. 2008. 
  • Bounhoure JP, Bottineau G, Lechat P, et al.. "Value of perindopril in the treatment of chronic congestive heart failure: multicentre double-blind placebo-controlled study." Clin Exp Hypertens. 1989;A11(suppl 2):575-586.
  • Lechat P, Granham SP, Desche P, et al.. "Efficacy and acceptability of perindopril in mild-to-moderate chronic congestive heart failure." Am Heart J. 1993;126:798-806.
  • Morgan T and Anderson A; "Clinical efficacy of perindopril in hypertension." Clin Exp Pharmacol Physiol. 1992;19:61-65.
  • Myers MG; (on behalf of the perindopril multicentre dose-response study group) "A dose-response study of perindopril in hypertension: effects on blood pressure 6 and 24h after dosing." Can J Cardiol. 1996;12:1191-1196.
  • "The European trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomized, double-blind, placebo controlled, multicentre trial (the EUROPA study)." The Lancet 2003;362:782-788.

Spoljašnje veze

[уреди | уреди извор]


Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).