Kruppel like factor 4 (Q21114206)

http://www.ebi.ac.uk/interpro/protein/O43474

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

21 March 2016

language of work or name

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

phosphatidylinositol 3-kinase regulator activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

DNA-binding transcription factor activity

3 references

8 April 2019

Klf4 is a transcription factor required for establishing the barrier function of the skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

1 reference

8 April 2019

Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

DNA-binding transcription activator activity, RNA polymerase II-specific

NAS

4 references

10 September 2018

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43474&geneProductId=UniProtKB:O43474

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43474&geneProductId=UniProtKB:O43474

8 April 2019

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

transcription factor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

double-stranded DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

promoter-specific chromatin binding

1 reference

8 April 2019

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

transcription coregulator binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

histone deacetylase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

transcription regulator complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

3 references

negative regulation of chemokine (C-X-C motif) ligand 2 production

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

epidermal cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to retinoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of protein kinase B signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of muscle hyperplasia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of protein metabolic process

1 reference

8 April 2019

A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

regulation of axon regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to peptide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43474&geneProductId=UniProtKB:O43474

positive regulation of hemoglobin biosynthetic process

1 reference

8 April 2019

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

response to retinoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

somatic stem cell population maintenance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to laminar fluid shear stress

TAS

1 reference

8 April 2019

A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

regulation of transcription by RNA polymerase II

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43474&geneProductId=UniProtKB:O43474

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

epidermis morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to growth factor stimulus

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

post-embryonic hemopoiesis

1 reference

8 April 2019

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of gene expression

1 reference

8 April 2019

Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of response to cytokine stimulus

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of cell migration involved in sprouting angiogenesis

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of gene expression

1 reference

8 April 2019

Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

post-embryonic camera-type eye development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

regulation of phosphatidylinositol 3-kinase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of telomerase activity

1 reference

8 April 2019

Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

canonical Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

mesodermal cell fate determination

1 reference

8 April 2019

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of heterotypic cell-cell adhesion

TAS

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to cycloheximide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of inflammatory response

1 reference

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of transcription by RNA polymerase II

TAS

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to hydrogen peroxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of leukocyte adhesion to arterial endothelial cell

1 reference

8 April 2019

Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of core promoter binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

cellular response to leukemia inhibitory factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of angiogenesis

1 reference

8 April 2019

Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

pri-miRNA transcription by RNA polymerase II

1 reference

8 April 2019

Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

negative regulation of G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of transcription, DNA-templated

4 references

8 April 2019

Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

8 April 2019

Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43474

has part(s)

Zinc finger C2H2-type

1 reference

stated in

InterPro Release 71.0