Broad and potent neutralization of HIV-1 by a gp41-specific human antibody (Q27675131)

Barton F Haynes

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Peter D. Kwong

Peter D Kwong

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Nicole Doria-Rose

Nicole A Doria-Rose

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Bimal K. Chakrabarti

Bimal Chakrabarti

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Richard T. Wyatt

Richard Wyatt

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Mark K. Louder

Mark K Louder

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Nancy S Longo

Nancy S Longo

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Yongping Yang

Yongping Yang

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Gilad Ofek

Gilad Ofek

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Jinghe Huang

Jinghe Huang

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Stephen A Migueles

Stephen A Migueles

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Hiromi Imamichi

Hiromi Imamichi

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Munir Alam

S Munir Alam

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Baoshan Zhang

Baoshan Zhang

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Robert Bailer

Robert T Bailer

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Mark Connors

Mark Connors

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Shailendra Sharma

Shailendra K Sharma

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author name string

Leo Laub

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Tao Wang

Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals

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language of work or name

English

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publication date

15 November 2012

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published in

Nature

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volume

491

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issue

7424

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page(s)

406-12

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cites work

1 reference

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

20 March 2017

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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

20 March 2017

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Elicitation of structure-specific antibodies by epitope scaffolds

20 March 2017

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A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

20 March 2017

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Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

20 March 2017

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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

20 March 2017

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

20 March 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

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Overview of the CCP4 suite and current developments

20 March 2017

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Phasercrystallographic software

20 March 2017

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Inference of macromolecular assemblies from crystalline state

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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PHENIX: building new software for automated crystallographic structure determination

20 March 2017

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Satisfying hydrogen bonding potential in proteins

20 March 2017

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Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

20 March 2017

1 reference

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

20 March 2017

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Broad neutralization coverage of HIV by multiple highly potent antibodies

7 April 2017

1 reference

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

7 April 2017

1 reference

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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

7 April 2017

1 reference

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Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

7 April 2017

1 reference

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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

7 April 2017

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Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site

29 September 2017

1 reference

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Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design

29 September 2017

1 reference

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Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions

29 September 2017

1 reference

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Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting

29 September 2017

1 reference

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Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

29 September 2017

1 reference

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MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.

29 September 2017

1 reference

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Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop

29 September 2017

1 reference

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A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals

29 September 2017

1 reference

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Rational antibody-based HIV-1 vaccine design: current approaches and future directions

29 September 2017

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Specificities of broadly neutralizing anti-HIV-1 sera

29 September 2017

1 reference

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Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables

29 September 2017

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Role of HIV membrane in neutralization by two broadly neutralizing antibodies

29 September 2017

1 reference

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Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Immunization against endogenous retroviral tumor-associated antigens.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Human immunodeficiency virus type 1 quasi species that rebound after discontinuation of highly active antiretroviral therapy are similar to the viral quasi species present before initiation of therapy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854285

Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23151583

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE11544

1 reference

Dimensions Publication ID

1003615458

0 references

1 reference

1 reference

PubMed publication ID

23151583

1 reference