Mechanism of activation of the prokaryotic channel ELIC by propylamine: a single-channel study (Q41640531)

5 October 2017

Mechanism of activation of the prokaryotic channel ELIC by propylamine: a single-channel study (English)

1 reference

5 October 2017

Lucia Sivilotti

0 references

Alessandro Marabelli

1 reference

PMC publication ID

4278187

5 October 2017

Remigijus Lape

series ordinal

1 reference

5 October 2017

1 January 2015

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The Journal of General Physiology

5 October 2017

1 reference

5 October 2017

145

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5 October 2017

1 reference

5 October 2017

23-45

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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

5 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Intramembrane proton binding site linked to activation of bacterial pentameric ion channel

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Principles of activation and permeation in an anion-selective Cys-loop receptor

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Ion conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

A prokaryotic perspective on pentameric ligand-gated ion channel structure

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Detection and trapping of intermediate states priming nicotinic receptor channel opening

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

On the nature of partial agonism in the nicotinic receptor superfamily

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

A stepwise mechanism for acetylcholine receptor channel gating

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

How to impose microscopic reversibility in complex reaction mechanisms

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

The activation mechanism of alpha1 homomeric glycine receptors

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

The quality of maximum likelihood estimates of ion channel rate constants

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Mapping the conformational wave of acetylcholine receptor channel gating

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC)

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Desensitization mechanism in prokaryotic ligand-gated ion channel

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates ("flip").

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Stochastic properties of ion channel openings and bursts in a membrane patch that contains two channels: evidence concerning the number of channels present when a record containing only single openings is observed.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

The kinetic properties of the α3 rat glycine receptor make it suitable for mediating fast synaptic inhibition.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Perspectives on: conformational coupling in ion channels: allosteric coupling in ligand-gated ion channels

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of alpha 1 glycine receptors in HEK293 cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Desensitized states prolong GABAA channel responses to brief agonist pulses.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278187

Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms

18 August 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411234

The distributions of the apparent open times and shut times in a single channel record when brief events cannot be detected

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411234

Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411234

Stochastic Properties of Ion Channel Openings and Bursts in a Membrane Patch that Contains Two Channels: Evidence Concerning the Number of Channels Present when a Record Containing Only Single Openings is Observed

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411234

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411234

Thinking in cycles: MWC is a good model for acetylcholine receptor-channels

21 January 2018

1 reference

12 December 2020

Recovery from open channel block by acetylcholine during neuromuscular transmission in zebrafish

1 reference

12 December 2020

A receptor for protons in the nerve cell membrane

1 reference

12 December 2020

The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine

1 reference

12 December 2020

Identifiers

DOI

10.1085/JGP.201411234

1 reference

5 October 2017

1 reference

PMC publication ID

4278187

5 October 2017

PubMed publication ID

25548135

1 reference

PMC publication ID

4278187