Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding. (Q46631754)

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3 April 2020

title

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding (English)

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3 April 2020

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3 April 2020

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3 April 2020

Christopher A. Cottrell

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3 April 2020

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3 April 2020

Dennis R Burton

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3 April 2020

Andrew B Ward

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3 April 2020

Gabriel Ozorowski

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3 April 2020

Jon M Steichen

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3 April 2020

Xiaozhen Hu

1 reference

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3 April 2020

Torben Schiffner

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3 April 2020

Alessia Liguori

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3 April 2020

Erik Georgeson

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3 April 2020

Oleksandr Kalyuzhniy

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3 April 2020

Jordan R Willis

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3 April 2020

Michael Kubitz

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3 April 2020

Yumiko Adachi

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3 April 2020

Samantha M Reiss

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3 April 2020

Mia Shin

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3 April 2020

Natalia de Val

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3 April 2020

William R Schief

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3 April 2020

Colin Havenar-Daughton

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3 April 2020

language of work or name

English

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publication date

21 November 2017

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3 April 2020

published in

Nature Communications

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3 April 2020

volume

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3 April 2020

issue

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3 April 2020

page(s)

1655

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Creative Commons Attribution 4.0 International

3 April 2020

start time

21 November 2017

1 reference

April 2022 Public Data File from Crossref

copyrighted

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24 May 2018

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24 May 2018

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24 May 2018

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Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

24 May 2018

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Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

24 May 2018

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24 May 2018

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Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

The evolution within us

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24 May 2018

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24 May 2018

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HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

24 May 2018

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Antibody responses to envelope glycoproteins in HIV-1 infection

24 May 2018

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Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design

24 May 2018

1 reference

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Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection

24 May 2018

1 reference

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Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

24 May 2018

1 reference

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A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component

24 May 2018

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Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks

24 May 2018

1 reference

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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

HIV-1 envelope glycoprotein trimer immunogenicity elicited in the presence of human CD4 alters the neutralization profile

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

CD4-induced activation in a soluble HIV-1 Env trimer

24 May 2018

1 reference

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Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies

24 May 2018

1 reference

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

HIV-1 neutralizing antibodies: understanding nature's pathways

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model

24 May 2018

1 reference

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Germinal center B cells govern their own fate via antibody feedback

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

24 May 2018

1 reference

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RELION: implementation of a Bayesian approach to cryo-EM structure determination

24 May 2018

1 reference

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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

24 May 2018

1 reference

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Structural informatics, modeling, and design with an open-source Molecular Software Library (MSL).

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

RosettaHoles2: a volumetric packing measure for protein structure refinement and validation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Therapeutic antibodies, vaccines and antibodyomes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Antibody polyspecificity and neutralization of HIV-1: a hypothesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5698488

10.1038/S41467-017-01549-6

24 May 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29162799%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29162799%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

PubMed publication ID

29162799

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29162799%20AND%20SRC:MED&resulttype=core&format=json