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ATOH1

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ATOH1
Identifiers
AliasesATOH1, ATH1, HATH1, MATH-1, bHLHa14, atonal bHLH transcription factor 1
External IDsOMIM: 601461; MGI: 104654; HomoloGene: 31297; GeneCards: ATOH1; OMA:ATOH1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005172

NM_007500

RefSeq (protein)

NP_005163

NP_031526

Location (UCSC)Chr 4: 93.83 – 93.83 MbChr 6: 64.71 – 64.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.[5][6]

Function

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This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with TCF3 (E47).[6] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.

In 2009, ATOH1 was identified as a tumor suppressor gene. [7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172238Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073043Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (September 1996). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics. 5 (9): 1207–16. doi:10.1093/hmg/5.9.1207. hdl:11858/00-001M-0000-0010-50D1-1. PMID 8872459.
  6. ^ a b "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)".
  7. ^ "Cancer 'switch-off' gene found". 2009-02-24. Archived from the original on 2009-02-27.
  8. ^ Bossuyt W, Kazanjian A, De Geest N, Van Kelst S, De Hertogh G, Geboes K, et al. (February 2009). "Atonal homolog 1 is a tumor suppressor gene". PLOS Biology. 7 (2): e39. doi:10.1371/journal.pbio.1000039. PMC 2652388. PMID 19243219.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.