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GSPT2

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GSPT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSPT2, ERF3B, GST2, G1 to S phase transition 2
External IDsOMIM: 300418; MGI: 1316727; HomoloGene: 99786; GeneCards: GSPT2; OMA:GSPT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018094

NM_008179

RefSeq (protein)

NP_060564

NP_032205

Location (UCSC)Chr X: 51.74 – 51.75 MbChr X: 93.68 – 93.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.[5][6]

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM][6]

Interactions

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GSPT2 has been shown to interact with PABPC1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189369Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071723Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hansen LL, Jakobsen CG, Justesen J (Jan 2000). "Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping". Cytogenet Cell Genet. 86 (3–4): 250–1. doi:10.1159/000015353. PMID 10575220. S2CID 44348876.
  6. ^ a b "Entrez Gene: GSPT2 G1 to S phase transition 2".
  7. ^ Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T (Jun 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. 274 (24). UNITED STATES: 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q8IYD1 (Human Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)) at the PDBe-KB.