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IL22RA1

From Wikipedia, the free encyclopedia

IL22RA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL22RA1, CRF2-9, IL22R, IL22R1, interleukin 22 receptor subunit alpha 1
External IDsOMIM: 605457; MGI: 2663588; HomoloGene: 10943; GeneCards: IL22RA1; OMA:IL22RA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021258

NM_178257

RefSeq (protein)

NP_067081

NP_839988

Location (UCSC)Chr 1: 24.12 – 24.14 MbChr 4: 135.46 – 135.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.[5]

Function

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The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142677Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037157Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Interleukin 22 receptor, alpha 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.